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:: Volume 14, Issue 2 (4-2016) ::
IJRR 2016, 14(2): 91-98 Back to browse issues page
Percutaneous microwave ablation of thyroid nodules: efficacy evaluation with 99m Tc - pertechnetate and 99mTc-MIBI functional imaging
K. Heck Dr. , Y. Korkusuz , C. Happel , F. Grünwald , H. Korkusuz
Frankfurt University Hospital , kristina.heck@web.de
Abstract:   (1711 Views)

Background: Local ablative treatments play an important role for patients who cannot be treated surgically. Radiofrequency ablation is a well-established alternative to surgical treatment of thyroid nodules, however it also has disadvantages. Microwave ablation (MWA) is a new minimally invasive treatment promising several improvements. The aim of this retrospective study was to evaluate the effects of microwave ablation on thyroid nodules by 99mTc-pertechnetate and 99mTc-MIBI scintigraphy. Materials and Methods: 30 patients with overall 40 nodules were treated. For the ablation of thyroid nodules, a microwave generator working with frequencies from 902 to 928 MHz was used. The ablation time ranged between 120 and  300 seconds per ablation zone. The target temperatures ranged between 60-80 °C. Pre- and post- interventional, the radionuclide uptake was determined using a thyroid specific scintillation camera. For 27 cold nodules 99mTc-MIBI was used for evaluation; 13 indifferent nodules were measured with 99mTc-pertechnetate. Results: The relative change of uptake was detected as a quotient of pre- and post- therapeutic uptake. The statistical analysis of scintigraphy data proved the efficacy of microwave ablation. 99mTc-pertechnetate scintigraphy  showed an uptake reduction of 39% (range 9 to 85%). 99mTc-MIBI imaging showed a median reduction of 40% (p<0.01) (range 7 to 100%). Conclusion: The determined results show the effectiveness of MWA as a treatment option for benign thyroid nodules. With functional scintigraphy a significant activity decrease could be detected in the ablation zone; hence a verification of affectivity was possible after a short period of time.

Keywords: Thyroid nodules, microwave ablation, 99mTc-pertechnetate scintigraphy, 99mTc-MIBI scintigraphy, functional imaging
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Type of Study: Original Research | Subject: Radiation Biology
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DOI: 10.18869/acadpub.ijrr.14.2.91

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Heck K, Korkusuz Y, Happel C, Grünwald F, Korkusuz H. Percutaneous microwave ablation of thyroid nodules: efficacy evaluation with 99m Tc - pertechnetate and 99mTc-MIBI functional imaging. IJRR. 2016; 14 (2) :91-98
URL: http://ijrr.com/article-1-1711-en.html
Volume 14, Issue 2 (4-2016) Back to browse issues page
International Journal of Radiation Research
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