|
Meta-analysis of the association between miR-499 gene polymorphism and hepatocellular carcinoma HCC genetic susceptibility
|
C. Xiaobo   , D. Hui , Y. Juan |
| Xiaogan Central Hospital, Xiaogan 432000, China , yj87920@126.com |
|
|
Abstract: (633 Views) |
Background: The link between the miR-499(rs3746444) gene polymorphism and genetic predisposition to hepatocellular carcinoma (HCC) was thoroughly assessed in this study. Materials and Methods: This study used Rev-Man 5.41 statistical software to conduct a meta-analysis of case-control studies that investigated the relationship between genetic susceptibility to HCC and the miR-499 gene or the rs3746444 locus polymorphism. The articles were searched in PMC, PubMed, and other databases. Results: In this analysis, 15 publications were used, with 4901 normal individuals serving as the control group and 3366 HCC patients as members of the experimental group. The findings showed that the risk of getting HCC was higher in those with the AA (95%CI (0.64, 0.94), I2 = 71%, P = 0.009) or AG (95%CI (1.01, 1.40), I2 = 58%, P = 0.04) genotypes. The risk of HCC was minimal when the genotype was GG (95%CI (0.79, 1.50), I2=56%, P = 0.60). A statistical difference was found between the G allele (95%CI (1.13, 1.69), I2 = 60%, P=0.002), while no significant difference was found between the two groups with respect to the A allele (95%CI (0.56, 1.15), I2 = 79%, P = 0.23). Conclusions: There was a strong link between the polymorphism of miR-499 gene and the genetic predisposition to hepatocellular cancer. Therefore, the polymorphism of the miR-499 gene can be utilized as a predictor of liver cancer occurrence, which is highly relevant for the early detection and management of liver cancer. |
|
| Keywords: Hepatocellular carcinoma, genetic susceptibility, miR-499 polymorphism, meta-analysis, liver cancer. |
|
|
Full-Text [PDF 1336 kb]
(182 Downloads)
|
|
Type of Study: Original Research |
Subject:
Radiation Biology
|
|
|
|
|
|
|
| References |
1. Ranjha R, Meena NK, Singh A, Ahuja V, Paul J (2017) Association of miR-196a-2 and miR-499 variants with ulcerative colitis and their correlation with expression of respective miRNAs. PLoS One, 12: e0173447. [ DOI:10.1371/journal.pone.0173447] 2. Zou H, Li M, Lei Q, Luo Z, Xue Y, Yao D, et al. (2022) Economic burden and quality of life of hepatocellular carcinoma in greater China: A systematic review. Frontiers in Public Health, 10: 801981. [ DOI:10.3389/fpubh.2022.801981] 3. Yang JD, Hainaut P, Gores GJ, Amadou A, Plymoth A & Roberts LR (2019) A global view of hepatocellular carcinoma: trends, risk, prevention and management. Nature Reviews Gastroenterology & Hepatology, 16(10): 589-604. [ DOI:10.1038/s41575-019-0186-y] 4. Yang TH, Chan C, Yang PJ, Huang YH & Lee MH (2023) Genetic Susceptibility to Hepatocellular Carcinoma in Patients with Chronic Hepatitis Virus Infection. Viruses, 15(2): 559. [ DOI:10.3390/v15020559] 5. Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F (2021) Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin, 71: 209-249. [ DOI:10.3322/caac.21660] 6. Zhang CH, Xu GL, Jia WD, Li JS, Ma JL, Ge YS (2011) Effects of interferon treatment on development and progression of hepatocellular carcinoma in patients with chronic virus infection: a meta-analysis of randomized controlled trials. Int J Cancer, 129: 1254-1264. [ DOI:10.1002/ijc.25767] 7. Xu X, Tao Y, Shan L, Chen R, Jiang H, Qian Z, et al. (2018) The role of MicroRNAs in hepatocellular carcinoma. Journal of Cancer, 9(19): 3557. [ DOI:10.7150/jca.26350] 8. Wang J, Li J, Chen L, Fan Z & Cheng J (2020) MicroRNA-499 suppresses the growth of hepatocellular carcinoma by downregulating astrocyte elevated gene-1. Technology in Cancer Research & Treatment, 19: 1533033820920253. [ DOI:10.1177/1533033820920253] 9. Buurman R, Gürlevik E, Schäffer V, Eilers M, Sandbothe M, et al. (2012) Histone deacetylases activate hepatocyte growth factor signaling by repressing microRNA-449 in hepatocellular carcinoma cells. Gastroenterology, 143(3): 811-820. [ DOI:10.1053/j.gastro.2012.05.033] 10. Ma YS, Shi BW, Lu HM, Xie PF, Xin R, Wu ZJ, et al. (2021) MicroRNA-499 serves as a sensitizer for lung cancer cells to radiotherapy by inhibition of CK2α-mediated phosphorylation of p65. Molecular Therapy-Oncolytics, 21: 171-182. [ DOI:10.1016/j.omto.2021.03.016] 11. Chong YC, Lim TE, Fu Y, Shin EM, Tergaonkar V, Han W (2019) Indian Hedgehog links obesity to development of hepatocellular carcinoma. Oncogene, 38: 2206-2222. [ DOI:10.1038/s41388-018-0585-5] 12. Nachtigall PG, Dias MC, Carvalho RF, Martins C, Pinhal D (2015) MicroRNA-499 expression distinctively correlates to target genes sox6 and rod1 profiles to resolve the skeletal muscle phenotype in Nile tilapia. PLoS One, 10(3): e0119804. [ DOI:10.1371/journal.pone.0119804] 13. Yang J, Liu J, Chen Y, Tang W, Liu C, Sun Y, Chen J (2019) Association of CTLA-4 tagging polymorphisms and haplotypes with hepatocellular carcinoma risk: A case-control study. Medicine (Baltimore), 98: e16266. [ DOI:10.1097/MD.0000000000016266] 14. Zhang S, Lin J, Jiang J, Chen Y, Tang W, Liu L (2019) Association between methylenetetrahydrofolate reductase tagging polymorphisms and susceptibility of hepatocellular carcinoma: a case-control study. Biosci Rep, 39. [ DOI:10.1042/BSR20192517] 15. Zhang S, Jiang J, Chen Z, Wang Y, Tang W, Chen Y, Liu L (2018) Relationship of PPARG, PPARGC1A, and PPARGC1B polymorphisms with susceptibility to hepatocellular carcinoma in an eastern Chinese Han population. Onco Targets Ther, 11: 4651-4660. [ DOI:10.2147/OTT.S168274] 16. Li J, Jin B, Wang T, Li W, Wang Z, Zhang H, Song Y, Li N (2019) Serum microRNA expression profiling identifies serum biomarkers for HCV-related hepatocellular carcinoma. Cancer Biomark, 26: 501-512. [ DOI:10.3233/CBM-181970] 17. Wei W, Hu Z, Fu H, Tie Y, Zhang H, Wu Y, Zheng X (2012) MicroRNA-1 and microRNA-499 downregulate the expression of the ets1 proto-oncogene in HepG2 cells. Oncol Rep, 28: 701-706. [ DOI:10.3892/or.2012.1850] 18. Pettinelli P, Arendt BM, Teterina A, McGilvray I, Comelli EM, Fung SK, Fischer SE, Allard JP (2018) Altered hepatic genes related to retinol metabolism and plasma retinol in patients with non-alcoholic fatty liver disease. PLoS One, 13: e0205747. [ DOI:10.1371/journal.pone.0205747] 19. Xiang Y, Fan S, Cao J, Huang S, Zhang LP (2012) Association of the microRNA-499 variants with susceptibility to hepatocellular carcinoma in a Chinese population. Mol Biol Rep, 39: 7019-7023. [ DOI:10.1007/s11033-012-1532-0] 20. Shan YF, Huang YH, Chen ZK, Huang KT, Zhou MT, Shi HQ, et al. (2012) miR-499A>G rs3746444 and miR-146aG>C expression and hepatocellular carcinoma risk in the Chinese population. Genet Mol Res, 12: 5365-5371. [ DOI:10.4238/2013.November.7.11] 21. Wang XH, Wang FR, Tang YF, Zou HZ, Zhao YQ (2014) Association of miR-149C>T and miR-499A>G polymorphisms with the risk of hepatocellular carcinoma in the Chinese population. Genet Mol Res, 13: 5048-5054. [ DOI:10.4238/2014.July.4.20] 22. Kyung TM, Jong WK, Young JJ, Moon JJ, So YC, Doyeun Oh, Nam KK (2012) Association of the miR-146aC > G, 149C > T, 196a2C > T, and 499A > G polymorphisms with colorectal cancer in the Korean population. Mol Carcinog, 51 Suppl 1: E65-73. doi: 10.1002/mc.21849. Epub 2011 Dec 7. [ DOI:10.1002/mc.21849] 23. Li X, Li K, Wu Z (2015) Association of four common SNPs in microRNA polymorphisms with the risk of hepatocellular carcinoma. Int J Clin Exp Pathol, 8: 9560-9566. 24. Fteah AM, Ahmed AI, Mosaad NA, Hassan MM, Mahmoud SH (2019) Association of MicroRNA 196a and 499 Polymorphisms with Development of Cirrhosis and Hepatocellular Carcinoma Post-HCV Infection in Egyptian Patients. Asian Pac J Cancer Prev, 20: 3479-3485. [ DOI:10.31557/APJCP.2019.20.11.3479] 25. Abdel-Hamid M, Elshaer S, Darwish A (2018) Association of MicroRNA related single nucleotide polymorphisms 196A-2 and 499 with the risk of hepatocellular carcinoma in Egyptian patients. Meta Gene, 16: 139-142. [ DOI:10.1016/j.mgene.2018.02.007] 26. Zhang LH, Hao BB, Zhang CY, Dai XZ, Zhang F (2016) Contributions of polymorphisms in miR146a, miR196a, and miR499 to the development of hepatocellular carcinoma. Genet Mol Res, 15. [ DOI:10.4238/gmr.15038582] 27. Yan P, Xia M, Gao F, Tang G, Zeng H, Yang S, Zhou H, Ding D, Gong L (2015) Predictive role of miR-146a rs2910164 (C>G), miR-149 rs2292832 (T>C), miR-196a2 rs11614913 (T>C) and miR-499 rs3746444 (T>C) in the development of hepatocellular carcinoma. Int J Clin Exp Pathol, 8: 15177-15183. 28. Kou JT, Fan H, Han D, Li L, Li P, Zhu J, Ma J, Zhang ZH, He Q (2014) Association between four common microRNA polymorphisms and the risk of hepatocellular carcinoma and HBV infection. Oncol Lett, 8: 1255-1260. [ DOI:10.3892/ol.2014.2257] 29. Zhou J, Lv R, Song X, Li D, Hu X, Ying B, Wei Y, Wang L (2012) Association between two genetic variants in miRNA and primary liver cancer risk in the Chinese population. DNA Cell Biol, 31: 524-530. [ DOI:10.1089/dna.2011.1340] 30. Zhang S, Chen L, Wang Y, Tang W, Chen Y, Liu L (2020) Investigation of the association of miRNA-499, miRNA-146a, miRNA-196a2 loci with hepatocellular carcinoma risk: A case-control study involving 1507 subjects. DNA Cell Biol, 39: 379-388. [ DOI:10.1089/dna.2019.5145] 31. Farokhizadeh Z, Dehbidi S, Geramizadeh B, Yaghobi R, Malekhosseini SA, Behmanesh M, Sanati MH, Afshari A, Moravej A, Karimi MH (2019) Association of microRNA polymorphisms with hepatocellular carcinoma in an Iranian population. Ann Lab Med, 39: 58-66. [ DOI:10.3343/alm.2019.39.1.58] 32. Qi JH, Wang J, Chen J, Shen F, Huang JT, Sen S, Zhou X, Liu SM (2014) High-resolution melting analysis reveals genetic polymorphisms in microRNAs confer hepatocellular carcinoma risk in Chinese patients. BMC Cancer, 14: 643. [ DOI:10.1186/1471-2407-14-643] 33. Chu YH, Hsieh MJ, Chiou HL, Liou YS, Yang CC, Yang SF, Kuo WH (2014) MicroRNA gene polymorphisms and environmental factors increase patient susceptibility to hepatocellular carcinoma. PLoS One, 9: e89930. [ DOI:10.1371/journal.pone.0089930] 34. Ranjha R, Meena NK, Singh A, Ahuja V, Paul J (2017) Association of miR-196a-2 and miR-499 variants with ulcerative colitis and their correlation with expression of respective miRNAs. PLoS One, 12: e0173447. [ DOI:10.1371/journal.pone.0173447] 35. Pinter M, Trauner M, Peck-Radosavljevic M & Sieghart W (2016) Cancer and liver cirrhosis: implications on prognosis and management. ESMO open, 1(2): e000042. [ DOI:10.1136/esmoopen-2016-000042] 36. Akkiz H, Bayram S, Bekar A, Akgöllü E, Üsküdar O (2011) Genetic variation in the microRNA-499 gene and hepatocellular carcinoma risk in a Turkish population: lack of any association in a case-control study. Asian Pac J Cancer Prev, 12: 3107-3112. 37. Gaviria-Calle M, Duque-Jaramillo A, Aranzazu M, Di Filippo D, Montoya M, Roldán I, Palacio N, Jaramillo S, Restrepo JC, Hoyos S, Navas MC (2018) Polymorphisms in alcohol dehydrogenase (ADH1) and cytochrome p450 2E1 (CYP2E1) genes in patients with cirrhosis and/or hepatocellular carcinoma. Biomedica, 38: 555-568. [ DOI:10.7705/biomedica.v38i4.3897] 38. Liu J, Yang HI, Lee MH, Jen CL, Hu HH, Lu SN, et al (2016) Alcohol drinking mediates the association between polymorphisms of ADH1B and ALDH2 and hepatitis B-related hepatocellular carcinoma. Cancer Epidemiol Biomarkers Prev, 25: 693-699. [ DOI:10.1158/1055-9965.EPI-15-0961] 39. Udali S, Guarini P, Ruzzenente A, Ferrarini A, Guglielmi A, Lotto V, et al. (2015) DNA methylation and gene expression profiles show novel regulatory pathways in hepatocellular carcinoma. Clin Epigenetics, 7: 43. [ DOI:10.1186/s13148-015-0077-1] 40. Fteah AM, Ahmed AI, Mosaad NA, Hassan MM, Mahmoud SH (2019) Association of MicroRNA 196a and 499 polymorphisms with development of cirrhosis and hepatocellular carcinoma Post-HCV infection in egyptian patients. Asian Pacific Journal of Cancer Prevention: APJCP, 20(11): 3479. [ DOI:10.31557/APJCP.2019.20.11.3479] 41. Allam MM, Diab KA, Khalil FO, Khalaf FA, Abdel-Samiee M, Sheble N, et al. (2022) The association between micro-RNA gene polymorphisms and the development of hepatocellular carcinoma in Egyptian patients. Archives of Medical Science: AMS, 18(1): 62. [ DOI:10.5114/aoms/100600] 42. Shen JH, Li YL, Li D, Wang NN, Jing L & Huang YH (2015) The rs738409 (I148M) variant of the PNPLA3 gene and cirrhosis: a meta-analysis. Journal of lipid research, 56(1): 167-175. [ DOI:10.1194/jlr.M048777] 43. Chakrabortty A, Patton DJ, Smith BF & Agarwal P (2023) miRNAs: Potential as Biomarkers and Therapeutic Targets for Cancer. National Library of Medicine, 14(7):1375. [ DOI:10.3390/genes14071375] |
|
| Send email to the article author |
|
|
|
| Add your comments about this article |
|
|
|
|
Xiaobo C, Hui D, Juan Y. Meta-analysis of the association between miR-499 gene polymorphism and hepatocellular carcinoma HCC genetic susceptibility. Int J Radiat Res 2024; 22 (3) :733-738 URL: http://ijrr.com/article-1-5657-en.html
|
