en Radiation Biology Radiation Biology تحقيق بديع Original Research <div style="text-align: justify;"><span style="font-size:10pt"><span style="text-justify:newspaper"><span style="text-kashida-space:50%"><span style="line-height:119%"><span style="font-family:Calibri"><span style="color:black"><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Background:</span></span></span></span></span></span> <span lang="en-GB" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-GB">Gastroesophageal reflux (GER) is a common complication after radiotherapy, potentially influenced by changes in esophageal sphincter pressure and nutrition tube placement. To investigate the relationship between Nas jejunal-gastric (NG-J) tube application and abnormal esophageal sphincter pressure in elderly patients with GER after radiotherapy. </span></span></span></span><span lang="en-GB" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-GB">Materials and Methods: </span></span></span></span></span></span><span lang="en-GB" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-GB">A prospective observational study was conducted on elderly patients with confirmed GER who underwent external beam radiotherapy for thoracic or head-and-neck malignancies between 2022 and 2024. Radiotherapy was delivered using intensity-modulated radiotherapy (IMRT) with a total dose of 50-70 Gy in daily fractions of 1.8-2.0 Gy. Esophageal manometry was performed before and within 1 month after radiotherapy. Patients requiring NG-J tube feeding were compared to those without tube placement. </span></span></span></span><span lang="en-GB" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-GB">Results: </span></span></span></span></span></span><span lang="en-GB" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-GB">Among 86 patients, 38 received NG-J tube feeding and 48 did not. Post-radiotherapy, the NG-J tube group showed a significantly greater reduction in lower esophageal sphincter pressure (-12.4 &plusmn; 3.2 mmHg vs. -6.8 &plusmn; 2.9 mmHg, p<0.001) and a higher incidence of severe GER symptoms (63.2% vs. 33.3%, p=0.005). Radiation dose to the lower esophagus (>60 Gy) correlated with a greater decline in sphincter pressure (r = -0.58, p<0.001). </span></span></span></span><span lang="en-GB" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-GB">Conclusion: </span></span></span></span></span></span><span lang="en-GB" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-GB">NG-J tube application in elderly patients after high-dose radiotherapy is associated with more pronounced reductions in esophageal sphincter pressure and increased GER severity. Careful tube management and minimizing esophageal radiation exposure may reduce complications.</span></span></span></span></span></span></span></span></span></span></div> Gastroesophageal reflux, esophageal sphincter, lower, manometry, radiotherapy, intensity-modulated, radiation dosage, enteral nutrition, Nasojejunal tube. 353 358 http://ijrr.com/browse.php?a_code=A-10-1-1501&slc_lang=en&sid=1 Y. Cao 7900319475328460033414 7900319475328460033414 No Department of Neurology, Eighth People's Hospital of Hebei Province, Shijiazhuang, 050011, China J. Zhao zhaojing820714@163.com 7900319475328460033415 7900319475328460033415 Yes Department of Neurology, Eighth People's Hospital of Hebei Province, Shijiazhuang, 050011, China S. Wang 7900319475328460033416 7900319475328460033416 No Department of Neurology, Eighth People's Hospital of Hebei Province, Shijiazhuang, 050011, China X. Zhou 7900319475328460033417 7900319475328460033417 No Department of Neurology, Eighth People's Hospital of Hebei Province, Shijiazhuang, 050011, China X. Du 7900319475328460033418 7900319475328460033418 No Department of Neurology, Eighth People's Hospital of Hebei Province, Shijiazhuang, 050011, China Y. Qin 7900319475328460033419 7900319475328460033419 No Department of Neurology, Eighth People's Hospital of Hebei Province, Shijiazhuang, 050011, China