International Journal of Radiation Research

en Evaluation of 68Ga-PSMA PET/CT in the staging of patients with prostate cancer Radiation Biology Radiation Biology تحقيق بديع Original Research <div style="text-align: justify;">Background: Targeting prostate-specific membrane antigen (PSMA), with Gallium-68 PSMA-directed Positron Emission Tomography/Computed Tomography (68Ga-PSMA PET/CT) is advanced imaging technique for prostate cancer (PCa) diagnosis. The current study evaluated the performance of 68Ga-PSMA PET/CT for staging and follow-up of PCa patients. Material and Methods: 54 newly diagnosed (Group I) and 66 recurrent PCa patients (Group II) underwent estimation of serum total prostate-specific antigen (PSAT), calculation of PSA density (PSAD), and grading by the Gleason grading system. After obtaining the whole-body images using the integrated PET/CT scanner, Discovery IQ five-ring machine, and PET scanning, the maximum standardized uptake (SUV-max) values were calculated. Histopathology is the gold standard for assessment of the diagnostic performance of 68Ga-PSMA PET/CT for Group II. Results: The PSAT levels and density for Group I increased progressively with Gleason grade, with significant (P=0.021 and P=0.005, respectively) differences among grades. The lymph nodes and local tumor SUV-max were remarkably higher (P<0.001 & 0.01) in Group I. The SUV-max according to PSAT grades of Group I patients showed a significant (P<0.001) difference. There was positive, significant (P<0.001) relation between PSAD and SUV-max. The regression model for PSAD versus SUV-max was significant. The natural log of SUV-max increased by 2.03-fold with each fold increase in the natural log of PSAD. Conclusion: Integrating 68Ga-PSMA PET/CT in the diagnostic workup for PCa patients helps the management decision-making and is particularly valuable for lesions in areas inaccessible for biopsy, or if PSA levels are in the diagnostic gray-zone.</div> Prostate cancer, prostate-specific membrane antigen, prostate-specific antigen density, 68Ga-PSMA PET/CT. 397 403 http://ijrr.com/browse.php?a_code=A-10-1-1508&slc_lang=en&sid=1 M.M.M. Shehata mahmoud.shehata007@gmail.com 7900319475328460033502 7900319475328460033502 Yes Department of Diagnostic Radiology, Faculty of Medicine, Ain Shams University, Cairo, Egypt H.A. Kader Morsy 7900319475328460033503 7900319475328460033503 No Department of Diagnostic Radiology, Faculty of Medicine, Ain Shams University, Cairo, Egypt R.S.E. Hussein 7900319475328460033504 7900319475328460033504 No Department of Diagnostic Radiology, Faculty of Medicine, Ain Shams University, Cairo, Egypt A.A.M. Okba 7900319475328460033505 7900319475328460033505 No Department of Diagnostic Radiology, Faculty of Medicine, Ain Shams University, Cairo, Egypt