International Journal of Radiation Research

en Cerebral artery stenosis causing ischemic stroke assessed with high-resolution magnetic resonance vascular-wall imaging (HR-VW-MRI) Radiation Biology Radiation Biology تحقيق بديع Original Research <div style="text-align: justify;">Background: To investigate the impact of plaque characteristics of mild to moderate stenotic middle cerebral artery atherosclerosis (ICAD) on the formation of plaques responsible for ischemic stroke (IS). Materials and Methods: A retrospective study on patients with mild to moderate stenotic middle cerebral artery atherosclerosis from December 2019 to December 2024. Patients were divided into two cohorts according to whether the plaque was responsible for IS based on high-resolution magnetic resonance vascular-wall imaging (HR-VW-MRI). Propensity score matching was also used to assign patients to plaque and non-plaque IS groups. Univariate and multivariate logistic regression analyses, along with receiver operating characteristic (ROC) curve analysis, were performed to assess the impact of plaque characteristics on IS-related plaque formation. Results: IS-related plaques had significantly higher volume and steepness than non-IS-related plaques (P<0.05), and there were notable differences in remodeling mode and bleeding. Logistic regression showed that the remodeling method (odds ratio (OR) = 0.547), plaque volume (OR=1.092), and plaque steepness (OR=1.089) were independent predictors of IS-related plaque formation. ROC curve analysis showed an area under the curve (AUC) of 0.620 for the remodeling method, 0.718 for plaque volume, and 0.711 for plaque steepness. The combined predictive model achieved an AUC of 0.795. Conclusion: Plaque remodeling, volume, and steepness are key factors that influence the formation of IS-related plaques. Their joint application could enhance the prediction of such plaques and aid in early detection and treatment.</div> High-resolution vessel wall magnetic resonance imaging, intracranial atherosclerotic stenosis, ischemic stroke, plaque. 417 422 http://ijrr.com/browse.php?a_code=A-10-1-1511&slc_lang=en&sid=1 F. Zhang fengling4097@hotmail.com 7900319475328460033517 7900319475328460033517 Yes Department of Radiology, Beijing Geriatric Hospital, Beijing 100095, China Y. Zhang 7900319475328460033518 7900319475328460033518 No Department of Neurology, Beijing Geriatric Hospital, Beijing 100095, China J. Liu 7900319475328460033519 7900319475328460033519 No Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China Y. Hu 7900319475328460033520 7900319475328460033520 No Department of Information Center, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China G. Liu 7900319475328460033521 7900319475328460033521 No Department of Radiology, Beijing Geriatric Hospital, Beijing 100095, China