en Radiation Biology Radiation Biology تحقيق بديع Original Research <div style="text-align: justify;"><span style="font-size:10pt"><span style="text-justify:newspaper"><span style="text-kashida-space:50%"><span style="line-height:119%"><span style="font-family:Calibri"><span style="color:black"><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Background:</span></span></span></span></span></span> <span lang="en-GB" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-GB">This study evaluated the impact of mind-mapping health interventions on nutritional status, renal function, and inflammatory markers in nasopharyngeal carcinoma (NPC) patients undergoing radiotherapy. </span></span></span></span><span lang="en-GB" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-GB">Materials and Methods: </span></span></span></span></span></span><span lang="en-GB" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-GB">A retrospective analysis was conducted on 120 NPC patients treated with intensity-modulated radiotherapy (66-70 Gy, 2 Gy/fraction over 6-7 weeks) at the First Affiliated Hospital of Harbin Medical University (2022-024). Patients were assigned to either standard care (n=60) or mind-mapping intervention (n=60). The intervention incorporated structured education on nutrition, symptom control, behavioral management, and renal monitoring using visual mind maps. Nutritional indicators [standardized dietary energy intake (NDEI), standardized dietary protein intake (NDPI), body mass index (BMI), mid-arm muscle circumference (MAMC)], renal parameters [serum creatinine (Scr), blood urea nitrogen (BUN), glomerular filtration rate (GFR)], and inflammatory markers [C-reactive protein (CRP), interleukin-6 (IL-6)] were assessed at baseline and 2, 4, and 6 weeks. Radiotherapy-related complications were recorded. </span></span></span></span><span lang="en-GB" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-GB">Results: </span></span></span></span></span></span><span lang="en-GB" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-GB">The intervention group demonstrated a significantly lower incidence of complications (8.3% vs. 21.7%, P=0.031). Nutritional indices improved markedly at 6 weeks (NDEI: 140.5&plusmn;21.2 vs. 125.4&plusmn;20.1 kJ/kg/day; NDPI: 1.42&plusmn;0.33 vs. 1.25&plusmn;0.27 g/kg/day; P<0.05). Renal function was preserved with reduced Scr (60.1&plusmn;12.0 vs. 70.2&plusmn;13.2 &micro;mol/L) and BUN, and higher GFR (P<0.05). CRP (6.0&plusmn;1.8 vs. 8.2&plusmn;2.1 mg/L) and IL-6 (9.2&plusmn;2.7 vs. 13.0&plusmn;3.2 pg/mL) were significantly lower in the intervention group. </span></span></span></span><span lang="en-GB" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-GB">Conclusion: </span></span></span></span></span></span><span lang="en-GB" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-GB">Mind-mapping interventions effectively reduce radiotherapy-related complications, enhance nutrition, preserve renal function, and mitigate inflammation in NPC patients. Their integration into clinical practice may improve radiotherapy outcomes.</span></span></span></span></span></span></span></span></span></span></div> Nasopharyngeal neoplasms, radiotherapy, nutrition assessment, renal insufficiency, inflammation, patient-centered care. 429 434 http://ijrr.com/browse.php?a_code=A-10-1-1513&slc_lang=en&sid=1 X. Li 18646324500@163.com 7900319475328460033532 7900319475328460033532 Yes Department of Nephrology, The First Affiliated Hospital of Harbin Medical University, Harbin, 150001, China X. Zhang 7900319475328460033533 7900319475328460033533 No Department of Nephrology, The First Affiliated Hospital of Harbin Medical University, Harbin, 150001, China Y. Hu 7900319475328460033534 7900319475328460033534 No Department of Nephrology, The First Affiliated Hospital of Harbin Medical University, Harbin, 150001, China