International Journal of Radiation Research

en Effects of extraperitoneal lymph node dissection vs. imaging methods on survival in staging before radiotherapy in advanced cervical cancer Radiation Biology Radiation Biology تحقيق بديع Original Research <div style="text-align: justify;">Background: Effects of extraperitoneal lymph node (LN) dissection and imaging on survival were investigated in staging before primary radiotherapy in locally-advanced cervical cancer (LACC). Materials and Methods: This retrospective study included 145 LACC patients (IIB-IVA 2018 FIGO) between December 2010 and April 2024 at Selcuk University, Faculty of Medicine. Sixty-four patients undergoing surgical staging (Group 1) and 81 undergoing staging through magnetic resonance imaging (MRI),  computed tomography (CT), and positron emission tomography CT (PET-CT) (Group 2) were evaluated. Pelvic or extended-field radiotherapy treatment was administered for para-aortic LN positivity. The effects on survival were statistically analyzed using the staging method. Results: Mean age of 145 cases was calculated as 60.0±11.8 (33-93 years). Mean diameter of cervical primary mass was calculated as 51.3±16.4 mm.  Histological type was determined as squamous cells in 134 cases (92.4%). Forty-eight (33.1%), 72 (49.7%), and 25 (17.2%) cases were determined as stages II, III, and IV, respectively; additionally, recurrence was detected in 38 cases (26.2%). In Group 1, removed median pelvic and paraaortic LNs were calculated as four (0-42) and nine (2-24), respectively. While para-aortic LN and isolated pelvic positivities were detected in one (1.6%) and 16 cases (25.0%) and respectively, both pelvic and para-aortic LN positivity was detected in 12 cases (18.8%). Surgical staging revealed a statistically significant difference regarding more locoregional-recurrence-free survival (p=0.026), distant-metastasis-free survival (p=0.023), progression-free survival (p=0.035), and overall survival (p=0.016) than imaging staging. Conclusion: We found that surgical staging had a better prognosis for survival than imaging methods in LACC staging.</div> Cervical cancer, computed tomography, lymph node, magnetic resonance imaging, positron emission tomography computed tomography, radiotherapy. 449 456 http://ijrr.com/browse.php?a_code=A-10-1-1516&slc_lang=en&sid=1 H. Basaran drhbasaran@gmail.com 7900319475328460033546 7900319475328460033546 Yes Department of Radiation Oncology, Medical Faculty of Selcuk University, Konya, Turkiye C. Celik 7900319475328460033547 7900319475328460033547 No Department of Obstetrics and Gynecology, Medical Faculty of Selcuk University, Konya, Turkiye A. Bilgi 7900319475328460033548 7900319475328460033548 No Department of Obstetrics and Gynecology, Medical Faculty of Selcuk University, Konya, Turkiye O. Onder Eren 7900319475328460033549 7900319475328460033549 No Department of Medical Oncology, Medical Faculty of Selcuk University, Konya, Turkiye M. Duzova 7900319475328460033550 7900319475328460033550 No Department of Radiation Oncology, Medical Faculty of Selcuk University, Konya, Turkiye B. Deli 7900319475328460033551 7900319475328460033551 No Department of Radiation Oncology, Medical Faculty of Selcuk University, Konya, Turkiye G. Yavas 7900319475328460033552 7900319475328460033552 No Department of Radiation Oncology, Etlik City Hospital, Ministry of Health, Ankara, Turkiye C. Yavas 7900319475328460033553 7900319475328460033553 No Department of Radiation Oncology, Medical Faculty of Selcuk University, Konya, Turkiye F. Avci 7900319475328460033554 7900319475328460033554 No Department of Obstetrics and Gynecology, Medical Faculty of Selcuk University, Konya, Turkiye