en Radiation Biology Radiation Biology تحقيق بديع Original Research <div style="text-align: justify;"><span style="font-size:10pt"><span style="text-justify:newspaper"><span style="text-kashida-space:50%"><span style="line-height:119%"><span style="font-family:Calibri"><span style="color:black"><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Background:</span></span></span></span></span></span> <span lang="en-GB" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-GB">This study aimed to explore using computed tomography (CT) images synthesized from magnetic resonance (MR) images by the 2.5D semi-supervised generative adversarial nets (SSGAN) framework to enhance the precision of intensity-modulated radiotherapy (IMRT) planning in patients with cervical cancer. </span></span></span></span><span lang="en-GB" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-GB">Materials and Methods: </span></span></span></span></span></span><span lang="en-GB" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-GB">A comprehensive pelvic MR-CT dataset, encompassing T1-weighted MR and CT volumes from 174 subjects, was utilized. This dataset was divided into training (n = 150) and test (n = 24) sets for model development and assessment. The Hounsfield Unit (HU) discrepancy and dosimetric accuracy of synthetic CT (sCT) images generated by 2.5D SSGAN were evaluated against actual CT images for cervical cancer IMRT planning. </span></span></span></span><span lang="en-GB" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-GB">Results: </span></span></span></span></span></span><span lang="en-GB" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-GB">The mean gamma analyses values for 2D criteria of 1 mm/1%, 2 mm/2%, and 3 mm/3% in these planes were 92.18% &plusmn; 4.64%, 98.13% &plusmn; 3.05%, and 99.23% &plusmn; 1.52%, respectively. Absolute dose deviations averaged 0.51% &plusmn; 0.18% within the regions of interest (ROIs). </span></span></span></span><span lang="en-GB" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-GB">Conclusion: </span></span></span></span></span></span><span lang="en-GB" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-GB">SSGAN accurately synthesized CT images from MR images, maintaining high dosimetric accuracy essential for cervical cancer IMRT planning.</span></span></span></span></span></span></span></span></span></span></div> Magnetic resonance imaging, radiotherapy planning, cervical cancer, Generative adversarial network, synthetic computed tomography. 527 533 http://ijrr.com/browse.php?a_code=A-10-1-1529&slc_lang=en&sid=1 D. Jiang 7900319475328460033674 7900319475328460033674 No Radiotherapy Center, Hubei Key Laboratory of Tumor Biological Behaviors, Hubei Cancer Clinical Study Center, Zhongnan Hospital of Wuhan University, Wuhan, China Y. Tian 7900319475328460033675 7900319475328460033675 No Radiotherapy Center, Hubei Key Laboratory of Tumor Biological Behaviors, Hubei Cancer Clinical Study Center, Zhongnan Hospital of Wuhan University, Wuhan, China X. Peng 7900319475328460033676 7900319475328460033676 No Radiotherapy Center, Hubei Key Laboratory of Tumor Biological Behaviors, Hubei Cancer Clinical Study Center, Zhongnan Hospital of Wuhan University, Wuhan, China L. Yang yangl_zn@163.com 7900319475328460033677 7900319475328460033677 Yes Radiotherapy Center, Hubei Key Laboratory of Tumor Biological Behaviors, Hubei Cancer Clinical Study Center, Zhongnan Hospital of Wuhan University, Wuhan, China H. Liu hbzkznyy@163.com 7900319475328460033678 7900319475328460033678 No Radiotherapy Center, Hubei Key Laboratory of Tumor Biological Behaviors, Hubei Cancer Clinical Study Center, Zhongnan Hospital of Wuhan University, Wuhan, China