International Journal of Radiation Research

en A novel averaging method for reducing systematic and random errors in breast cancer radiotherapy using electronic portal imaging device Radiation Biology Radiation Biology تحقيق بديع Original Research <div style="text-align: justify;">Background: The aim of this study is to introduce a novel averaging method to reduce systematic and random errors using electronic portal imaging device (EPID) in breast cancer radiotherapy. Materials and methods: Data from 78 female breast cancer patients, treated with photons beams of an Elekta Synergy linac were retrospectively analyzed. A novel five-session EPID averaging method (Optimized Five Session Averaging Method) was compared with a traditional three-session approach (Three Session Averaging Method) and a no-averaging approach (No Averaging Method). Statistical analysis was performed to compare the accuracy of the three methods. Results: The Optimized Five-Session Averaging Method demonstrated superior accuracy in minimizing individual mean set up errors compared to the Three-Session Averaging Method. Specifically, in the x direction, 71.80 of patients in the Optimized Five-Session Averaging Method had errors closer to zero, as opposed to 28.21 in the 2 Three-Session Averaging Method. In the y direction, 67.94 and 32.05 were closer to zero in the Optimized Five-Session Averaging Method and Three-Session Averaging Method, respectively. In the z direction, 70.51 and 29.49 achieved this in the Optimized Five-Session Averaging Method and Three-Session Averaging Method. Statistical analysis confirmed the significant difference between the two methods (p=0.00). Conclusion: The novel averaging method effectively enhanced the accuracy and reduced errors in breast cancer radiotherapy compared to the two conventional methods. This study provides a significant advancement in reducing patient set up error in breast cancer radiotherapy and highlights the potential of the Optimized Five-Session Averaging Method for optimization in diverse clinical contexts.</div> Breast cancer, radiotherapy, IGRT, setup error, EPID. 685 692 http://ijrr.com/browse.php?a_code=A-10-1-1564&slc_lang=en&sid=1 M. Khosravi 7900319475328460034272 7900319475328460034272 No Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran A. Shakeri 7900319475328460034273 7900319475328460034273 No Radiotherapy Center, Shahid Beheshti Hospital, Qom, Iran M. Khosroabadi 7900319475328460034274 7900319475328460034274 No Medical Physics Department, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran S.M. Hosseini 7900319475328460034275 7900319475328460034275 No Department of Medical Physics and Medical Engineering, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran G. Mehri-Kakavand Mehri-Kakavand 7900319475328460034276 7900319475328460034276 No Department of Anatomy and Medical Imaging, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand M. Pursamimi mohamadpursamimi65@gmail.com 7900319475328460034277 7900319475328460034277 Yes Department of Anatomy and Medical Imaging, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand W. Parwaie 7900319475328460034278 7900319475328460034278 No Department of Medical Physics, Faculty of Paramedical Sciences, Ilam University of Medical Sciences, Ilam, Iran M. Shafiee 7900319475328460034279 7900319475328460034279 No Radiotherapy Center, Shahid Beheshti Hospital, Qom, Iran M. Ghorbani mhdghorbani@gmail.com 7900319475328460034280 7900319475328460034280 No Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran M. Tavakoli 7900319475328460034281 7900319475328460034281 No Department of Radiation Oncology, Winship Cancer Institute, Emory University, Atlanta, GA, USA