International Journal of Radiation Research

en Correlation between MDCT and postoperative histopathology in the staging of laryngeal carcinoma Radiation Biology Radiation Biology تحقيق بديع Original Research <div style="text-align: justify;">Background: Laryngeal squamous cell carcinoma (LSCC) originates from the laryngeal mucosal epithelium. Multidetector contrast-enhanced computerized tomography (MDCT) is valuable staging tool for various cancers. Objectives are evaluation of the performance of preoperative staging of LSCC according to the interpretation of MDCT imaging compared to pathological staging of the surgically excised specimens. Materials and Methods: MDCT scanning was performed by 64-detector, multi-slice CT device, and injection of contrast material (Lohexal 75%). Surgically excised laryngeal specimens were examined pathologically and staged. The study outcome was the performance of the CT scanning versus pathological findings. Results: Excellent agreement was detected for most laryngeal regions with Kappa values >0.9. In terms of tumor staging, CT showed good agreement with pathology stagings (Kappa=0.557). Overall, CT shows excellent diagnostic utility, with accuracy rates of 73.3% to 96.7% with ≥90% sensitivity and 100% for LSCC in subglottic, paraglottic, preepiglottic, aryepiglottic folds, and vocal cord regions. Conclusion: Preoperative MDCT scanning for LSCC patients might accurately detect and stage lesions across the laryngeal regions. MDCT imaging could detect extra-laryngeal space invasion with perfect agreement with pathological staging.</div> Laryngeal squamous cell carcinoma, multidetector computerized tomography, pathological staging, diagnostic performance characteristics. 693 698 http://ijrr.com/browse.php?a_code=A-10-1-1565&slc_lang=en&sid=1 A.A.Y. Ellithy abdobasha2017@gmail.com 7900319475328460034283 7900319475328460034283 Yes Diagnostic Radiology Department, Otolaryngology Department, Pathology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt N. H. Shebrya 7900319475328460034284 7900319475328460034284 No Diagnostic Radiology Department, Otolaryngology Department, Pathology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt H. A. A. Elsersy 7900319475328460034285 7900319475328460034285 No Diagnostic Radiology Department, Otolaryngology Department, Pathology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt M.M. El-Mahdy 7900319475328460034286 7900319475328460034286 No Diagnostic Radiology Department, Otolaryngology Department, Pathology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt W.R. Abdel Hamed 7900319475328460034287 7900319475328460034287 No Diagnostic Radiology Department, Otolaryngology Department, Pathology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt