International Journal of Radiation Research

en The orienting-exploratory activity of rats after oral intake of industrial dust of uranium ore Radiation Biology Radiation Biology تحقيق بديع Original Research <div style="text-align: justify;">Background: The functional abnormalities of the nervous system induced by the injection of industrial dust of uranium ore (DUO) into rat’s organism were studied. Materials and Methods: DUO was administered to nonlinear white male rats orally during a week in an amount of 5.8 g daily. The calculation of the individual absorbed and equivalent doses in the organs and tissues of rats allowed to include them to the range of small doses of ionizing radiation. To calculate the doses received by the animals during the experiment, the uranium content in biological samples was determined using an Agilent-7800 inductively coupled plasma mass spectrometer. The behavior of experimental animals was observed in the test in an open field condition for a month after incorporation into the body of long-lived radionuclides. Results: Analysis of behavioral acts in a group of males exposed to DUO at a dose of 50 maximum permissible concentration (MPC) indicated the predominance of passive-defensive forms of behavior, which was manifested by a decrease in motor and exploratory activity. The noted changes were evident throughout the study. At the same time, a slowdown in habituation processes was recorded, manifested in a small variability in the number of crossed squares and the number of vertical posts. Conclusion: The intake of DUO at a dose of 50 MPC changed the indices of locomotor and research activity of rats significantly along with an increased concentration of uranium in the organs and tissues of animals, including the brain. </div> Indicative-research activity, ionizing radiation, nervous system, open field, uranium. 771 777 http://ijrr.com/browse.php?a_code=A-10-1-1576&slc_lang=en&sid=1 E.A. Saifulina saifulina.e@amu.kz 7900319475328460034383 7900319475328460034383 Yes Laboratory of Epidemiology and Medical Dosimetry Register of the Scientific Research Institute of Radiobiology and Radiation Protection, NpJSC “Astana Medical University”, Astana city, Kazakhstan P.K. Kazymbet 7900319475328460034384 7900319475328460034384 No Scientific Research Institute of Radiobiology and Radiation Protection of the nJSC, Astana Medical University, Astana, Kazakhstan A.А. Musina 7900319475328460034385 7900319475328460034385 No Department of Public Health and Epidemiology, NJSC, Astana Medical University, Astana, Kazakhstan В. Aitbayeva 7900319475328460034386 7900319475328460034386 No Department of Pathological Physiology named after V.G. Korpachyov NPJSC, Astana Medical University, Astana, Kazakhstan T. Kashkinbayev Ye 7900319475328460034387 7900319475328460034387 No Scientific Research Institute of Radiobiology and Radiation Protection of the nJSC, Astana Medical University, Astana, Kazakhstan D.S. Tazhibayeva 7900319475328460034388 7900319475328460034388 No Department of Pathological Physiology named after V.G. Korpachyov NPJSC, Astana Medical University, Astana, Kazakhstan K.A. Kusmambetova 7900319475328460034389 7900319475328460034389 No Department of Medical Genetics and Molecular Biology of the nJSC "Astana Medical University, Astana, Kazakhstan S.A. Tulepbergenova 7900319475328460034390 7900319475328460034390 No Department of Medical Genetics and Molecular Biology of the nJSC "Astana Medical University, Astana, Kazakhstan T.N. Tuleuov 7900319475328460034391 7900319475328460034391 No Department of Pathological Physiology named after V.G. Korpachyov NPJSC, Astana Medical University, Astana, Kazakhstan