en Radiation Biology Radiation Biology مقاله مروری Review article <div style="text-align: justify;"><span style="font-size:10pt"><span style="text-justify:newspaper"><span style="text-kashida-space:50%"><span style="line-height:119%"><span style="font-family:Calibri"><span style="color:black"><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Background:</span></span></span></span></span></span> <span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">Variability in treatment sensitivity and radiation-induced toxicity can adversely affect clinical outcomes. Objective: To evaluate the effectiveness and safety of integrating traditional Chinese medicine with radiotherapy in the treatment. </span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Materials and Methods: </span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">To identify eligible studies, a systematic search strategy was applied to five major biomedical databases. Radiotherapy mainly involved conventional external beam techniques, including three-dimensional conformal radiotherapy (3D-CRT), intensity-modulated radiotherapy (IMRT), and EBRT. TCM interventions consisted of injectable preparations and oral herbal formulas administered during or around radiotherapy. </span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Results: </span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">9 studies involving 655 patients were included. Combination therapy significantly improved objective response rate (RR = 1.44, P < 0.001) and reduced adverse outcomes (RR = 0.34, P < 0.001). CD4⁺T cells increased significantly (MD = 9.55, P < 0.001), whereas CD8⁺T-cell changes were nonsignificant (MD = &ndash;3.89, P = 0.280). The regimen also lowered gastrointestinal toxicity (RR = 0.52, P = 0.008) and myelosuppression (RR = 0.53, P < 0.001). The findings were validated through sensitivity analyses, demonstrating their robustness. </span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Conclusion: </span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">TCM combined with radiotherapy may enhance efficacy and reduce toxicity in breast cancer, warranting further large-scale trials.</span></span></span></span></span></span></span></span></span></div> Breast neoplasms, radiotherapy, medicine, Chinese traditional, immunity, meta-analysis. 867 874 http://ijrr.com/browse.php?a_code=A-10-1-1587&slc_lang=en&sid=1 Y.J. Yu 7900319475328460034465 7900319475328460034465 No Department of Breast and Thyroid Surgery, Yibin First People's Hospital, Yibin, Sichuan, China L.H. Zhu 7900319475328460034466 7900319475328460034466 No Department of Breast and Thyroid Surgery, Yibin First People's Hospital, Yibin, Sichuan, China W.C. Guo 106176227@qq.com 7900319475328460034467 7900319475328460034467 Yes Department of Vascular Surgery, Yibin First People's Hospital, Yibin, Sichuan, China