International Journal of Radiation Research
نشریه پرتو پژوه
Int J Radiat Res
Basic Sciences
http://ijrr.com
79
journal79
2322-3243
2345-4229
10.66224/ijrr
en
jalali
1405
4
1
gregorian
2026
7
1
24
3
online
1
fulltext
en
Low-dose radiotherapy as an anti-inflammatory strategy in neonatal hypoxic-ischemic encephalopathy
Radiation Biology
Radiation Biology
مقاله مروری
Review article
<div style="text-align: justify;"><span style="font-size:10pt"><span style="text-justify:newspaper"><span style="text-kashida-space:50%"><span style="line-height:119%"><span style="font-family:Calibri"><span style="color:black"><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Background:</span></span></span></span></span></span> <span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">Neonatal hypoxic-ischemic encephalopathy (HIE) affects 1–26 per 1,000 live births, driving sustained neuroinflammation via NF-</span></span></span><span lang="el" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:el">κ</span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">B activation, microglial M1 polarization, and cytokine storms (TNF-</span></span></span><span lang="el" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:el">α, </span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">IL-1</span></span></span><span lang="el" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:el">β, </span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">IL-6), causing secondary brain injury and disability in 40–50% of hypothermia-treated survivors. However, it remains unknown whether low-dose radiotherapy (LDRT, ≤0.1 Gy) resolves this previously elusive cascade through ATM–IKK–NF-</span></span></span><span lang="el" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:el">κ</span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">B suppression and microglial repolarization in preclinical models. </span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Materials and Methods: </span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">We systematically reviewed preclinical evidence on anti-inflammatory interventions in HIE, with focused synthesis of radiobiological studies using LDRT (≤0.1 Gy) across ischemic, neurodegenerative, and neuroinflammatory models (n > 15 independent reports). </span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Results: </span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">LDRT demonstrated 3–6-fold suppression of TNF-</span></span></span><span lang="el" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:el">α </span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">and IL-1</span></span></span><span lang="el" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:el">β (</span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">P < 0.001, 95% CI 2.8–7.1, n = 12 models) through ATM-dependent IKK inhibition. It uncovered microglial M2 repolarization with 4-fold IL-10 and 3.5-fold TGF-</span></span></span><span lang="el" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:el">β </span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">upregulation (P < 0.001). Combined with hypothermia, LDRT resolved previously inaccessible persistent inflammation, achieving 75–85% reduction in secondary injury biomarkers (oxidative stress, apoptosis; P < 0.001). </span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Conclusion: </span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">LDRT establishes a radiobiological framework that transforms multimodal neonatal neuroprotection, opening the door to precision anti-inflammatory strategies that mitigate inflammation-driven brain injury in HIE.</span></span></span></span></span></span></span></span></span></div>
Hypoxia-ischemia, brain, infant, newborn, inflammation, radiotherapy, neuroprotective agents, nf-kappa b, microglia.
909
915
http://ijrr.com/browse.php?a_code=A-10-1-1592&slc_lang=en&sid=1
X.
Du
7900319475328460034486
7900319475328460034486
No
School of Basic Medical Sciences, Guangdong Pharmaceutical University, Guangzhou 510006, China
L.
Luo
josephluoli@hotmail.com
7900319475328460034487
7900319475328460034487
No
School of Basic Medical Sciences, Guangdong Pharmaceutical University, Guangzhou 510006, China