[Home ] [Archive]    
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
Main Menu
IJRR Information::
For Authors::
For Reviewers::
News & Events::
Web Mail::
Search in website

Advanced Search
Receive site information
Enter your Email in the following box to receive the site news and information.
Hard Copy 2322-3243
Online 2345-4229
Online Submission
Now you can send your articles to IJRR office using the article submission system.



:: Volume 21, Issue 3 (6-2023) ::
Int J Radiat Res 2023, 21(3): 427-434 Back to browse issues page
Dosimetric characteristics of tomotherapy and three-dimensional conformal radiotherapy for head and neck cancer
N. Monadi , D. Shahbazi-Gahrouei , S. Monadi , L. Mahani , A. Shams , A. Akhavan , R. Mohammadi
Department of Medical Physics, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran , shahbazi@med.mui.ac.ir
Abstract:   (1175 Views)
Background: This study aims to evaluate and compare Three-Dimensional Conformal Radiotherapy (3D-CRT) versus Helical Tomotherapy (HT) based on treatment planning and selection of the most appropriate method to reduce side effects. Materials and Methods: Treatment planning was performed on images of 20 patients with head and neck cancer with lymph node involvement by HT and 3D-CRT techniques in Seyed Al-Shohada hospital, Isfahan, Iran. The quality of target coverage, the exposure of normal tissue, and radiation delivery efficiency in two studied methods were compared. Results: Tomotherapy showed significant improvement over 3D-CRT in terms of D2%, D50% Dmean, V95%, CI (conformity index), and HI (homogeneity index) for PTV (planning target volume) and in terms of D2%, D98%, Dmean, V95%, CI and HI for PTV Nodal. The mean dose received by 98% of PTV (D98%) increased in HT compared to 3D-CRT. Whereas, higher doses received in organs at risk (OARs) in 3D-CRT compared to HT. Conclusion: Results showed improvements in target quality for HT over 3D-CRT, including dosimetric coverage of target volumes, homogeneity and conformity indices, and reduction of the volume of cold and hot spots. Tomotherapy also performed better than that of 3D-CRT in OARs. Overall, with the satisfactory results obtained here, HT technique has considerable promise for treating head and neck cancers with the involvement of regional lymph nodes.
Keywords: Head and Neck Cancer, Conformity index, Homogeneity index, Radiotherapy, Three-Dimensional Conformal Radiation Therapy, Helical Tomotherapy.
Full-Text [PDF 840 kb]   (611 Downloads)    
Type of Study: Original Research | Subject: Radiation Biology
1. Ralston SH, Penman ID, Strachan MW, Hobson R (2022) Davidson's principles and practice of medicine. E-book: Elsevier health sciences, 24th ed., ISBN: 9780702083495
2. Shang Q, Shen ZL, Ward MC, et al. (2015) Evolution of treatment planning techniques in external-beam radiation therapy for head and neck cancer. Applied Radiation Oncology, 4:18-25. [DOI:10.37549/ARO1076]
3. Andrew DV, Gregory MM, Videtic NW (2014) Handbook of treatment planning. 2nd Ed., Springer Publishing Company, New York, United States.
4. Moroney LB, Helios J, Ward EC, et al. (2017) Patterns of dysphagia and acute toxicities in patients with head and neck cancer undergoing helical IMRT±concurrent chemotherapy. Oral Oncology, 64:1-2. [DOI:10.1016/j.oraloncology.2016.11.009] [PMID]
5. Low DA, Moran JM, Dempsey JF, et al. (2011) Dosimetry tools and techniques for IMRT. Medical Physics, 38(3):1313-38. [DOI:10.1118/1.3514120] [PMID]
6. Gupta T, Agarwal J, Jain S, et al. (2012) Three-dimensional conformal radiotherapy (3D-CRT) versus intensity modulated radiation therapy (IMRT) in squamous cell carcinoma of the head and neck: a randomized controlled trial. Radiotherapy & Oncology,104(3): 343-8. [DOI:10.1016/j.radonc.2012.07.001] [PMID]
7. Cheng HC, Wu VW, Ngan RK, et al. (2012) A prospective study on volumetric and dosimetric changes during intensity-modulated radiotherapy for nasopharyngeal carcinoma patients. Radiotherapy & Oncology, 104(3): 317-23. [DOI:10.1016/j.radonc.2012.03.013] [PMID]
8. Teoh M, Clark C, Wood K, et al. (2011) Volumetric modulated arc therapy: a review of current literature and clinical use in practice. The British Journal of Radiology, 84(1007): 967-96. [DOI:10.1259/bjr/22373346] [PMID] []
9. Bedford JL and Warrington AP (2009) Commissioning of volumetric modulated arc therapy (VMAT). Int J Radiat Oncolo Biol Phys, 73(2): 537-45. [DOI:10.1016/j.ijrobp.2008.08.055] [PMID]
10. Buettner F, Miah AB, Gulliford SL, et al. (2012) Novel approaches to improve the therapeutic index of head and neck radiotherapy: an analysis of data from the PARSPORT randomised phase III trial. Radiotherapy & Oncology, 103(1): 82-7. [DOI:10.1016/j.radonc.2012.02.006] [PMID]
11. Nutting CM, Morden JP, Harrington KJ, et al. (2011) Parotid-sparing intensity modulated versus conventional radiotherapy in head and neck cancer (PARSPORT): a phase 3 multicentre randomised controlled trial. The Lancet Oncology, 12(2): 127-36. [DOI:10.1016/S1470-2045(10)70290-4]
12. Elith C, Dempsey SE, Findlay N, et al. (2011) An introduction to the intensity-modulated radiation therapy (IMRT) techniques, tomotherapy, and VMAT. Journal of Medical Imaging & Radiation Sciences, 42(1): 37-43. [DOI:10.1016/j.jmir.2010.11.005] [PMID]
13. Jeraj R, Mackie TR, Balog J, et al. (2004) Radiation characteristics of helical tomotherapy. Medical Physics, 31(2): 396-404. [DOI:10.1118/1.1639148] [PMID]
14. Shen Q, Ma X, Hu W, et al. (2013) Intensity-modulated radiotherapy versus three-dimensional conformal radiotherapy for stage I-II natural killer/T-cell lymphoma nasal type: dosimetric and clinical results. Radiation Oncology, 8(1): 1-8. [DOI:10.1186/1748-717X-8-152] [PMID] []
15. Fiorino C, Dell'Oca I, Pierelli A, et al. (2006) Significant improvement in normal tissue sparing and target coverage for head and neck cancer by means of helical tomotherapy. Radiotherapy & Oncology, 78(3): 276-82. [DOI:10.1016/j.radonc.2006.02.009] [PMID]
16. Cao D, Holmes TW, et al. (2007) Comparison of plan quality provided by intensity-modulated arc therapy and helical tomotherapy. In J Radiat Oncol Biol Phys, 69(1):240-50. [DOI:10.1016/j.ijrobp.2007.04.073] [PMID]
17. Murthy V, Master Z, Gupta T, et al. (2010) Helical tomotherapy for head and neck squamous cell carcinoma: dosimetric comparison with linear accelerator-based step-and-shoot IMRT. Journal of Cancer Research & Therapeutics, 6(2): 194. [DOI:10.4103/0973-1482.65245] [PMID]
18. Rong Y, Tang G, Welsh JS, et al. (2011) Helical tomotherapy versus single-arc intensity-modulated arc therapy: a collaborative dosimetric comparison between two institutions. Int J Radiat Oncol Biol Phy, 81(1): 284-96. [DOI:10.1016/j.ijrobp.2010.10.059] [PMID]
19. Wiezorek T, Brachwitz T, Georg D, et al. (2011) Rotational IMRT techniques compared to fixed gantry IMRT and tomotherapy: multi-institutional planning study for head-and-neck cases. Radiation Oncology, 6(1):1-10. [DOI:10.1186/1748-717X-6-20] [PMID] []
20. Grégoire V and Mackie TR (2011) Optimized Treatment Planning For IMRT, comparison of 3D-Conformal and IMRT treatment planning. Cancer/Radiothérapie, 2011:17-25.
21. Ekici K, Pepele EK, Yaprak B, et al. (2016) Dosimetric comparison of helical tomotherapy, intensity-modulated radiation therapy, volumetric-modulated arc therapy, and 3-dimensional conformal therapy for the treatment of T1N0 glottic cancer. Medical Dosimetry, 41(4): 329-33. [DOI:10.1016/j.meddos.2016.08.002] [PMID]
22. Teng F, Fan W, Luo Y, et al. (2019) Reducing xerostomia by comprehensive protection of salivary glands in intensity-modulated radiation therapy with helical tomotherapy technique for head-and-neck cancer patients: a prospective observational study. BioMed Research International, 2019: 2401743. [DOI:10.1155/2019/2401743] [PMID] []
23. Santa Cruz O, Tsoutsou P, Castella C, et al. (2018) Locoregional control and toxicity in head and neck carcinoma patients following helical Tomotherapy-delivered intensity-modulated radiation therapy compared with 3D-CRT data. Oncology, 95:61-8. [DOI:10.1159/000489217] [PMID]
24. Leung SW and Lee TF (2013) Treatment of nasopharyngeal carcinoma by tomotherapy: five-year experience. Radiation Oncology, 8(1): 1-6. [DOI:10.1186/1748-717X-8-107] [PMID] []
25. Liu X, Huang E, Wang Y, et al. (2017) Dosimetric comparison of helical tomotherapy, VMAT, fixed-field IMRT and 3D-conformal radiotherapy for stage I-II nasal natural killer T-cell lymphoma. Radiation Oncology, 12(1):1-9. [DOI:10.1186/s13014-017-0812-1] [PMID] []
26. Nguyen NP, Smith-Raymond L, Vinh-Hung V, et al. (2011) Feasibility of Tomotherapy to spare the cochlea from excessive radiation in head and neck cancer. Oral Oncology, 47(5): 414-9. [DOI:10.1016/j.oraloncology.2011.03.011] [PMID]
27. Myers PA, Mavroidis P, Papanikolaou N, Stathakis S (2014) Comparing conformal, arc radiotherapy and helical tomotherapy in craniospinal irradiation planning. Journal of Applied Clinical Medical Physics, 15(5):4724. [DOI:10.1120/jacmp.v15i5.4724] [PMID] []
Send email to the article author

Add your comments about this article
Your username or Email:


XML     Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Monadi N, Shahbazi-Gahrouei D, Monadi S, Mahani L, Shams A, Akhavan A et al . Dosimetric characteristics of tomotherapy and three-dimensional conformal radiotherapy for head and neck cancer. Int J Radiat Res 2023; 21 (3) :427-434
URL: http://ijrr.com/article-1-4851-en.html

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 21, Issue 3 (6-2023) Back to browse issues page
International Journal of Radiation Research
Persian site map - English site map - Created in 0.06 seconds with 49 queries by YEKTAWEB 4642