:: Volume 13, Issue 3 (7-2015) ::
Int J Radiat Res 2015, 13(3): 251-257 Back to browse issues page
Trabecular bone changes induced by fast neutrons versus gamma rays in mice
Y. Yang, H.J. Lee, H. Jang, J.H. Lee, C. Moon, J.C. Kim, U. Jung, S.K. Jo, C.M. Kang, S.H. Kim
College of Veterinary Medicine, Chonnam National University, Gwangju, Republic of Korea , shokim@chonnam.ac.kr
Abstract:   (6306 Views)

Background: The trabecular bone changes in the tibia of C3H/HeN mice were measured 12 weeks after whole body irradiation with various doses of fast neutrons (0-2.4 Gy) or 137Cs-generated gamma-rays (0-6 Gy). Materials and Methods: Serum calcium, phosphorus, estradiol concentration and alkaline phosphatase activity were measured. Tibiae were analyzed using microcomputed tomography. Biomechanical property and osteoclast surface level were measured. Results: There was a significant relationship between the loss of bone architecture and the radiation dose, and the best-fitting dose-response curves were linear-quadratic. Mean relative biological effectiveness (RBE) values (Ref. gamma) of 2.05 and 2.33 were estimated for fast neutron irradiation in trabecular bone volume fraction and bone mineral density, respectively. There was a substantial reduction in osteoclast surface level in tartrate-resistant acid phosphatase-stained histological sections of tibial metaphyses in irradiated mice with high dose of neutrons. Conclusion: There was a significant relationship between the loss of bone architecture and the radiation dose. The difference of osteoclastic bone resorption may represent a contributor to the low RBE in high dose of irradiation level relative to that of low dose level.

Keywords: Neutrons, trabecular bone, osteoclast, relative biological effectiveness
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Type of Study: Original Research | Subject: Radiation Biology

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Volume 13, Issue 3 (7-2015) Back to browse issues page