:: Volume 13, Issue 4 (10-2015) ::
Int J Radiat Res 2015, 13(4): 305-316 Back to browse issues page
Nano selenium-lovastatin mixture modulate inflammatory cascade in arthritic irradiated model
Khaled Sh. Azab Dr. , N.M. Thabet, A.R.B. Abdel Ghaffar, A. Osman, A.I. El-Batal
Atomic Energy Authority , khshazab@hotmail.com
Abstract:   (5505 Views)

Background:  The development of nanotechnology has been a boon to mankind as its significance paved the way for several applications in therapeutics. This study was to evaluate the anti-arthritic capability of nano Selenium-lovastatin mixture (Lov-Se) against inflammatory cascade in arthritic irradiated rats. Materials and Methods: Animal model of Arthritis was organized by subcutaneous injection of Complete Freund’s adjuvant; CFA. Rats were exposed to γ-radiation (2Gy every 3 days up to total dose of 8 Gy). Lov-Se (1ml ≈ 20 mg kg−1 day−1Lov and 0.1 mg kg−1 day−1Se) was administrated by daily oral injection. The antioxidant parameters (heart glutathione peroxides; GSH-Px, catalase; CAT, superoxide dismutase; SOD, xanthine dehydrogenase; XDH, reduced glutathione; GSH and blood selenium; Se), oxidant markers (heart Xanthine oxidase; XO, Nitric oxide; NO, protein carbonyls and thiobarbituric acid reactive substances; TBARS) and the inflammatory molecules (serum tumor necrosis factor-alpha TNF-α, C-reactive protein; CRP and rheumatoid factor; RF) were determined. Results: The arthritic and arthritic irradiated rats were displayed augment oxidative stress, inflammatory cascade and impaired antioxidant status compared to control. Conclusion: The data revealed that Lov-Se administration ameliorate oxidative, antioxidants parameters as well as inflammatory factors. The prolonged administration of Lov-Se mixture in appropriate concentration could exert a considerable systemic anti-inflammatory action through adjustment of red-ox tone and the integration of XDH/XO ratio.

Keywords: Arthritis, γ-radiation, nano selenium-lovastatin, antioxidant, oxidative stress, inflammation
Full-Text [PDF 620 kb]   (1062 Downloads)    
Type of Study: Original Research | Subject: Radiation Biology



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Volume 13, Issue 4 (10-2015) Back to browse issues page