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:: Volume 14, Number 4 (10-2016) ::
IJRR 2016, 14(4): 279-285 Back to browse issues page
Optimal timing of computed tomography for assessing lymph nodes after neoadjuvant chemoradiotherapy for rectal cancer
C.L. Lai, M.J. Lai, C.H. Liu, C.C. Wu, S.W. Jao, Dr. C.W. Hsiao
Division of Colon and Rectal Surgery, Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, Republic of China
Abstract:   (998 Views)

Background: This study assessed the optimal timing of computed tomography for detection of metastatic disease in locoregional lymph nodes in patients with rectal cancer who have undergone chemoradiotherapy. Materials and Methods: This observational retrospective study was performed in a single institution. All patients with locally advanced rectal cancer treated with chemoradiotherapy, followed by a total mesorectum excision from January 1, 2003 to December 31, 2012, were included. Lymph node metastases evident on preoperative computed tomography were compared with postoperative pathologic lymph node status. Results: The study population consisted of 108 patients: Group A (nodal negative on preoperative computed tomography, n = 52) and Group B (nodal positive on preoperative computed tomography, n = 56). Analysis of the computed tomography scans in Group A revealed a high ability (98.07%) to predict negative lymph nodes, compared to 58.92% for predicting positive lymph nodes in Group B. Conclusion: The results of this study suggest that the optimal timing of computed tomography for assessing lymph nodes after neoadjuvant chemoradiotherapy for rectal cancer is after 6 weeks; this timing might be key for prediction of complete clinical responses.  

Keywords: Keywords: Computed tomography, chemoradiotherapy, rectum cancer, complete clinical response.
Full-Text [PDF 607 kb]   (331 Downloads)    
Type of Study: Reviews and Perspectives | Subject: Radiation Biology
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DOI: 10.18869/acadpub.ijrr.14.4.279


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Lai C, Lai M, Liu C, Wu C, Jao S, Hsiao C. Optimal timing of computed tomography for assessing lymph nodes after neoadjuvant chemoradiotherapy for rectal cancer. IJRR. 2016; 14 (4) :279-285
URL: http://ijrr.com/article-1-1812-en.html
Volume 14, Number 4 (10-2016) Back to browse issues page
International Journal of Radiation Research
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