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:: Volume 14, Issue 4 (10-2016) ::
IJRR 2016, 14(4): 279-285 Back to browse issues page
Optimal timing of computed tomography for assessing lymph nodes after neoadjuvant chemoradiotherapy for rectal cancer
C.L. Lai , M.J. Lai , C.H. Liu , C.C. Wu , S.W. Jao , C.W. Hsiao Dr.
Division of Colon and Rectal Surgery, Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, Republic of China
Abstract:   (1412 Views)

Background: This study assessed the optimal timing of computed tomography for detection of metastatic disease in locoregional lymph nodes in patients with rectal cancer who have undergone chemoradiotherapy. Materials and Methods: This observational retrospective study was performed in a single institution. All patients with locally advanced rectal cancer treated with chemoradiotherapy, followed by a total mesorectum excision from January 1, 2003 to December 31, 2012, were included. Lymph node metastases evident on preoperative computed tomography were compared with postoperative pathologic lymph node status. Results: The study population consisted of 108 patients: Group A (nodal negative on preoperative computed tomography, n = 52) and Group B (nodal positive on preoperative computed tomography, n = 56). Analysis of the computed tomography scans in Group A revealed a high ability (98.07%) to predict negative lymph nodes, compared to 58.92% for predicting positive lymph nodes in Group B. Conclusion: The results of this study suggest that the optimal timing of computed tomography for assessing lymph nodes after neoadjuvant chemoradiotherapy for rectal cancer is after 6 weeks; this timing might be key for prediction of complete clinical responses.  

Keywords: Keywords: Computed tomography, chemoradiotherapy, rectum cancer, complete clinical response.
Full-Text [PDF 607 kb]   (364 Downloads)    
Type of Study: Reviews and Perspectives | Subject: Radiation Biology
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DOI: 10.18869/acadpub.ijrr.14.4.279


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Lai C, Lai M, Liu C, Wu C, Jao S, Hsiao C. Optimal timing of computed tomography for assessing lymph nodes after neoadjuvant chemoradiotherapy for rectal cancer. IJRR. 2016; 14 (4) :279-285
URL: http://ijrr.com/article-1-1812-en.html
Volume 14, Issue 4 (10-2016) Back to browse issues page
International Journal of Radiation Research
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