60-year-old woman was treated for a brain metastasis. The patient received intensity-modulated radiation therapy (SIB-IMRT) dose of 30 Gy for the whole brain and 40 Gy delivered simultaneously to individual brain metastases in 10 fractions. The present report investigated the influence of applied novel prepared treatment plan, among others the fractionation protocol on the electroencephalogram (EEG) record.