[Home ] [Archive]    
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 15, Issue 3 (7-2017) ::
IJRR 2017, 15(3): 251-257 Back to browse issues page
Application of computed tomography and magnetic resonance imaging fusion images for delineating gross tumor volume in three-dimensional conformal radiotherapy of nasopharyngeal carcinoma
H. Chen , H. Huang Dr. , G. Li , D. Huang , S. Huang , Z. Wang
Department of Medical Oncology, the Fourth Affiliated Hospital of Guangxi Medical University, Liuzhou 545005, China , haixinhuangcn@163.com
Abstract:   (434 Views)
Background: To evaluate computed tomography (CT) and magnetic resonance imaging (MRI) fusion images for delineating gross tumor volume (GTV) in three-dimensional conformal radiotherapy (3D-CRT) of nasophanrygeal carcinoma (NPC), and compare treatment outcomes between CT- and CT+MRI-based targets. Materials and Methods: A total of 120 NPC patients treated with 3D-CRT were included, in which, 60 each were treated with CT-based and 60 with CT+MRI fusion targets. We explored the clinical application of CT+MRI fusion targets and compared the 1-, 3-, and 5-year survival and relapse rates between both targets. Results: The clinical characteristics and treatment factors were well balanced. The differences in public volume using CT alone in the CT+MRI (Group A) and the CT arm (Group B) were not significant (33.6±2.18 vs. 34.3±2.98, P > 0.05). The public volumes of GTV in the two arms were 49.48±2.46 cm3 and 33.6±2.18 cm3 respectively (P < 0.05). CT+MR fusion images did not influence the one-, three-, and 5-year survival rates (100% vs. 98.3%, 85.0% vs. 81.2%, and 73.3% vs. 68.3%, respectively). The three- and 5-year out-of-field progression was reduced in the CT+MRI arm. However, only the difference in 3-year out-of-field relapse rate was significant (3.3% vs. 13.3%; P < 0.05). The incidence of acute toxicities was similar between groups. Conclusion: The variability in GTV delineation in NPC was ascribed to intermodality and not interobserver variability. CT+MR fusion images likely reduced the 3-year out-of-field relapse rate.
 

 
Keywords: Nasophanrygeal carcinoma, image fusion, three-dimensional conformal radiation therapy.
Full-Text [PDF 538 kb]   (57 Downloads)    
Type of Study: Original Research | Subject: Radiation Biology
Send email to the article author

Add your comments about this article
Your username or Email:

Write the security code in the box >



XML     Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Chen H, Huang H, Li G, Huang D, Huang S, Wang Z. Application of computed tomography and magnetic resonance imaging fusion images for delineating gross tumor volume in three-dimensional conformal radiotherapy of nasopharyngeal carcinoma . IJRR. 2017; 15 (3) :251-257
URL: http://ijrr.com/article-1-2055-en.html
Volume 15, Issue 3 (7-2017) Back to browse issues page
International Journal of Radiation Research
Persian site map - English site map - Created in 0.048 seconds with 806 queries by yektaweb 3531