[Home ] [Archive]    
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 16, Issue 1 (1-2018) ::
Int J Radiat Res 2018, 16(1): 55-64 Back to browse issues page
Cytogenetic and biochemical competency of chamomile essential oil against γ-rays induced mutagenic effects in mice
S.S. Tawfik , M.M. Ahmed Dr. , Z.S. Said , M.R. Mohamed
Department of Radiation Biology, National Centre for Radiation Research and Technology, Egyptian Atomic Energy Authority, Nasr City, Egypt , Mahmoud_70mohameds@yahoo.com
Abstract:   (1314 Views)
Background: Chamomile essential oil (CEO) hauls out from Matricaria chamomilla L., is a well-known anti-oxidant. Oxidative stress induces clastogenic and biochemical disorders after γ-irradiation of animals. Materials and Methods: Mice were divided into five groups. Control group received vehicle only.                         CEO-treated group received CEO. Irradiated group received vehicle and exposed to                γ-rays. Pre-treated group received CEO ½h before γ-rays exposure. Post-treated group received CEO ½ hour after γ-rays exposure. Peripheral-blood micronucleus (PMN), bone-marrow micronucleus (BMN), frequency of chromosomal aberrations (CAs), reduced glutathione (GSH), malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (PGx) and myeloperoxidase (MPO), lactate dehydrogenase (LDH) and tumor necrosis factor-α (TNF-α) parameters were assessed. Results: In irradiated mice group, PMN score, BMN occurrence and CAs were increased when compared with control mice group. In addition, significant increases in levels of liver lipid peroxidation (LP); expressed as MDA and TNF-α. In addition, activities of liver MPO and LDH were found. Besides, significant decreases in content of GSH, activities of SOD and PGx in liver tissues were recognized. CEO treatment (1.0 g/kg body weight) before- and after-irradiation ameliorated all these biochemical indices, as well as cytogenetic alterations induced by γ-rays when compared with irradiated group, indicating that pre- or post-treatment with CEO significantly attenuates the acute hazards caused by γ-rays exposure. Conclusion: The data suggest that CEO possesses a radioprotective potential against γ-radiation induced cytogenetic and biochemical damages in mice.
 
Keywords: Chamomile oil, radioprotector, cytogenetic disorder, biochemical alteration, γ-rays.
Full-Text [PDF 603 kb]   (199 Downloads)    
Type of Study: Original Research | Subject: Radiation Biology
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA code


XML     Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Tawfik S, Ahmed M, Said Z, Mohamed M. Cytogenetic and biochemical competency of chamomile essential oil against γ-rays induced mutagenic effects in mice . Int J Radiat Res. 2018; 16 (1) :55-64
URL: http://ijrr.com/article-1-2142-en.html


Volume 16, Issue 1 (1-2018) Back to browse issues page
International Journal of Radiation Research
Persian site map - English site map - Created in 0.07 seconds with 32 queries by YEKTAWEB 3727