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:: Volume 17, Issue 3 (6-2019) ::
Int J Radiat Res 2019, 17(3): 393-400 Back to browse issues page
The effects of volumetric changes on radiation doses of the rectum and bladder during radiotherapy in patients with prostate cancer
E. Duman Dr. , Y. Bilek, N. Atabek
University of Health Sciences Antalya Training and Research Hospital, Department of Radiation Oncology, Antalya, Turkey' , evrimduman@hotmail.com
Abstract:   (218 Views)
Background: In prostate radiotherapy, changes in the volume of the bladder and rectum can influence dose delivery. In this study, cone-beam computerised tomography (CBCT) imaging was used to assess volumetric, and corresponding radiation dosimetric changes, for the bladder and rectum in patients with prostate cancer treated using VMAT. Materials and Methods: Treatment planning computed tomography (simCT) and CBCT images were retrospectively evaluated in 22 patients with prostate cancer. Bladder and rectal volumes were recontoured in 176 CBCT images. CBCT images were used for VMAT treatment plan recalculation and to obtain bladder and rectum radiation doses. Results: Mean rectal volumes measured by CBCT were significantly larger than those estimated by simCT (P=0.001). A 14% increase in rectum volume resulted in a 9% increase in mean rectum doses. The percent volumes (Vx) of the rectum receiving 40, 50, 60 and 70 Gy doses based on CBCT results were significantly larger than those based on simCT results (P=0.002, P=0.001, P=0.001, P 0.003, respectively). Mean bladder volumes measured by CBCT were significantly smaller than those estimated by simCT (P=0.001). A 13% decrease in bladder volume resulted in a 8% increase in mean bladder doses. Mean bladder V65 and V70 values based on CBCT results were significantly higher than those based on simCT results (P<0.001, P=0.002, respectively). Conclusion: Results during prostate radiotherapy, daily changes in bladder and rectal volumes can result in larger actual doses to these organs than the planned dose.
Keywords: Cone-beam computerized tomography, dosimetry, prostate cancer, radiotherapy, volumetric modulated arc therapy.
Full-Text [PDF 1697 kb]   (86 Downloads)    
Type of Study: Original Research | Subject: Radiation Biology
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Duman E, Bilek Y, Atabek N. The effects of volumetric changes on radiation doses of the rectum and bladder during radiotherapy in patients with prostate cancer . Int J Radiat Res. 2019; 17 (3) :393-400
URL: http://ijrr.com/article-1-2581-en.html


Volume 17, Issue 3 (6-2019) Back to browse issues page
International Journal of Radiation Research
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