:: Volume 2, Issue 1 (6-2004) ::
Int J Radiat Res 2004, 2(1): 27-34 Back to browse issues page
Logistic discriminant analysis of breast cancer using ultrasound measurements
P. Abdolmaleki, M. Mokhtari Dizaji, M.R. Vahead, M. Gity
Abstract:   (17222 Views)

Background: Logistic discriminant method was applied to differentiate malignant from benign in a group of patients with proved breast lesions on the basis of ultrasonic parameters.

Materials and Methods: Our database include 273 patients' ultrasonographic pictures consisting of 14 quantitative variables. The measured variables were ultrasound propagation velocity, acoustic impedence and attenuation coefficient at 10 MHz in breast lesions at 20, 25, 30 and 35 ยบ C temperature, physicsl density and age. This database was randomly divided into the estimation of 201 and validation of 72 samples. The estimation samples were used to build the logistic
discriminant model, and validation samples were used to validate the performance. Finally,
important criteria such as sensitivity, specificity, accuracy and area under the receiver operating characteristic curve (ROC) were evaluated.

Results: Our results showed that the logistic discriminant method was able to classify correctly 67 out of 72 cases presented in the validation sample. The results indicate a remarkable
diagnostic accuracy of 93%.

Conclusion: A logistic discriminantor approach is capable of predicting the probability of
malignancy of breast cancer. Features extracted from ultrasonic measurement on ultrasound imaging is used in this approach. Iran . J. Radiat. Res., 2004 2 (1): 27-34
Keywords: ultrasonic tissue characterization, ultrasonic imaging, logistic discriminant analysis, receiver operating characteristic curve (ROC)
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Type of Study: Original Research | Subject: Radiation Biology

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Volume 2, Issue 1 (6-2004) Back to browse issues page