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:: Volume 20, Issue 3 (7-2022) ::
Int J Radiat Res 2022, 20(3): 607-613 Back to browse issues page
Influence of lesion size on differential diagnosis of benign and malignant breast lesions by real-time two-dimensional shear wave elastography
W. Qu , N. He , X. Yang , C. Yuan , G. Zhang , J. Wei , X. Zheng
Department of Ultrasound, Anhui Provincial Hospital Affiliated to Anhui Medical University (First Affiliated Hospital of the University of Science and Technology of China), Lujiang Road, Hefei, Anhui,230001, China , henianan71@qq.com
Abstract:   (853 Views)
Background: The aim of this study was to evaluate the influence of lesion size on the performance of real-time two-dimensional shear wave elastography (2D-SWE) in the diagnosis of breast lesions. Materials and Methods: A total of 118 consecutive female patients with 129 breast lesions (50 malignant and 79 benign) who underwent surgical excision and/or core biopsy were studied. The lesions were categorized into three subgroups according to their size: (1) group 1: < 1.0 cm3; (2) group 2: 1.0–4.0 cm3; (3) group 3: > 4.0 cm3. The maximum elasticity (Emax), mean elasticity (Emean), and their standard deviation (SD) in the three subgroups were compared and analyzed in terms of the cutoff values acquired by pathological results. Results: The lesion size significantly differed between benign and malignant masses (P < 0.05). Malignant lesions exhibited significantly elevated values of Emax, Emean, and SD, compared with benign lesions in the three subgroups. The optimal threshold was higher for larger malignant and benign lesions (P < 0.05). In malignant lesions, the SWE parameters in group 1 were significantly different from those in groups 2 and 3. The area under the receiver operating characteristics curve (AUROC) of SD was higher than that of Emax and Emean in all three subgroups. Conclusion: The values of 2D-SWE parameters  increase with the increase in size of a breast mass, and the adjustment of the threshold based on lesion size yields a more accurate diagnosis. Among the SWE parameters, SD has the best diagnostic performance. 
Keywords: Ultrasound, shear wave, elastography, breast lesions, BI-RADS.
Full-Text [PDF 1695 kb]   (371 Downloads)    
Type of Study: Original Research | Subject: Radiation Biology
References
1. 1. Harbeck N and Gnant M (2017) Breast cancer. Lancet, 389(10074): 1134-1150. [DOI:10.1016/S0140-6736(16)31891-8]
2. DeSantis CE, Ma J, Goding Sauer A, Newman LA, Jemal A (2017) Breast cancer statistics, 2017, racial disparity in mortality by state. CA-Cancer J Clin, 67(6): 439-448. [DOI:10.3322/caac.21412] [PMID]
3. Chen WQ, Li H, Sun KX, Zheng RS, He J (2018) Report of Cancer Incidence and Mortality in China, 2014. Zhonghua Zhong Liu Za Zhi, 40(1): 5-13. [DOI:10.21147/j.issn.1000-9604.2018.01.01] [PMID] []
4. Du Y-R, Wu Y, Chen M, Gu X-G (2018) Application of contrast-enhanced ultrasound in the diagnosis of small breast lesions. Clin Hemorheol Micro, 70(3): 291-300. [DOI:10.3233/CH-170368] [PMID]
5. Marino MA, Riedl CC, Bernathova M, Bernhart C, Baltzer PAT, Helbich TH, Pinker K (2018) Imaging phenotypes in women at high risk for breast cancer on mammography, ultrasound, and magnetic resonance imaging using the fifth edition of the breast imaging reporting and data system. Eur J Radiol, 106: 150-159. [DOI:10.1016/j.ejrad.2018.07.026] [PMID] []
6. Fernandes J, Sannachi L, Tran WT, Koven A, Watkins E, Hadizad F, Gandhi S, Wright F, Curpen B, El Kaffas A, Faltyn J, Sadeghi-Naini A, Czarnota G (2019) Monitoring breast cancer response to neoadjuvant chemotherapy using ultrasound strain elastography. Transl Oncol, 12(9): 1177-1184. [DOI:10.1016/j.tranon.2019.05.004] [PMID] []
7. Kim JY, Shin JK, Lee SH (2015) The breast tumor strain ratio is a predictive parameter for axillary lymph node metastasis in patients with invasive breast cancer. Am J Roentgenol, 205(6): W630-W638. [DOI:10.2214/AJR.14.14269] [PMID]
8. Suvannarerg V, Chitchumnong P, Apiwat W, Lertdamrongdej L, Tretipwanit N, Pisarnturakit P, et al. (2019) Diagnostic performance of qualitative and quantitative shear wave elastography in differentiating malignant from benign breast masses, and association with the histological prognostic factors. Quant Imaging Med Surg, 9(3): 386-398. [DOI:10.21037/qims.2019.03.04] [PMID] []
9. Luo S, Yao G, Hong Z, Zhang S, Wang W, Zhang J, et al. (2019) Qualitative classification of shear wave elastography for differential diagnosis between benign and metastatic axillary lymph nodes in breast cancer. Front Oncol, 9: 533. [DOI:10.3389/fonc.2019.00533] [PMID] []
10. Hong S, Woo OH, Shin HS, Hwang S-Y, Cho KR, Seo BK (2017) Reproducibility and diagnostic performance of shear wave elastography in evaluating breast solid mass. Clin Imag, 44: 42-45. [DOI:10.1016/j.clinimag.2017.03.022] [PMID]
11. Skerl K, Vinnicombe S, Giannotti E, Thomson K, Evans A (2015) Influence of region of interest size and ultrasound lesion size on the performance of 2D shear wave elastography (SWE) in solid breast masses. Clin Radiol, 70(12): 1421-1427. [DOI:10.1016/j.crad.2015.08.010] [PMID]
12. Lin X, Chang C, Wu C, Chen Q, Peng Y, Luo B, Tang L, Li J, Zheng J, Zhou R, Cui G, Li A, Wang X, Qian L, Zhang J, Wen C, Gay J, Zhang H, Li A, Chen Y (2018) Confirmed value of shear wave elastography for ultrasound characterization of breast masses using a conservative approach in Chinese women: a large-size prospective multicenter trial. Cancer Manag Res, 10: 4447-4458. [DOI:10.2147/CMAR.S174690] [PMID] []
13. Giannotti E, Vinnicombe S, Thomson K, McLean D, Purdie C, Jordan L, Evans A (2016) Shear-wave elastography and greyscale assessment of palpable probably benign masses: Is biopsy always required? Br J Radiol, 89(1062): 20150865. [DOI:10.1259/bjr.20150865] [PMID] []
14. Cong R, Li J, Wang X (2017) Comparing performance of combinations of shear wave elastography and B-mode ultrasound in diagnosing breast masses: Is it influenced by mass size? Ultrasound Med Biol, 43(10): 2133-2143. [DOI:10.1016/j.ultrasmedbio.2017.04.015] [PMID]
15. Huang Y, Li F, Han J, Peng C, Li Q, Cao L, Liu Y, Zhou J (2019) Shear wave elastography of breast lesions: Quantitative analysis of elastic heterogeneity improves diagnostic performance. Ultrasound Med Biol, 45(8): 1909-1917. [DOI:10.1016/j.ultrasmedbio.2019.04.019] [PMID]
16. Chang JM, Moon WK, Cho N, Yi A, Koo HR, Han W, Noh D-Y, Moon H-G, Kim SJ (2011) Clinical application of shear wave elastography (SWE) in the diagnosis of benign and malignant breast diseases. Breast Cancer Res Treat, 129(1): 89-97. [DOI:10.1007/s10549-011-1627-7] [PMID]
17. Kim SJ, Ko KH, Jung HK, Kim H (2015) Shear wave elastography: Is it a valuable additive method to conventional ultrasound for the diagnosis of small (≤2 cm) breast cancer? Medicine, 94(42): e1540. [DOI:10.1097/MD.0000000000001540] [PMID] []
18. Ng WL, Rahmat K, Fadzli F, Rozalli FI, Mohd-Shah MN, Chandran PA, Westerhout CJ, Vijayananthan A, Abdul Aziz YF (2016) Shearwave elastography increases diagnostic accuracy in characterization of breast lesions. Medicine, 95(12): e3146. [DOI:10.1097/MD.0000000000003146] [PMID] []
19. Evans A, Sim YT, Thomson K, Jordan L, Purdie C, Vinnicombe SJ (2016) Shear wave elastography of breast cancer: Sensitivity according to histological type in a large cohort. Breast, 26: 115-118. [DOI:10.1016/j.breast.2016.01.009] [PMID]
20. Cosgrove D, Piscaglia F, Bamber J, Bojunga J, Correas JM, Gilja O, et al. (2013) EFSUMB guidelines and recommendations on the clinical use of ultrasound elastography. Part 2: Clinical applications. Eur J Ultrasound, 34(3): 238-253. [DOI:10.1055/s-0033-1335375] [PMID]
21. Barr RG, Nakashima K, Amy D, Cosgrove D, Farrokh A, Schafer F, et al. (2015) WFUMB guidelines and recommendations for clinical use of ultrasound elastography: Part 2: Breast. Ultrasound Med Biol, 41(5): 1148-1160. [DOI:10.1016/j.ultrasmedbio.2015.03.008] [PMID]
22. Chamming's F, Latorre-Ossa H, Le Frère-Belda MA, Fitoussi V, Quibel T, Assayag F, et al. (2013) Shear wave elastography of tumour growth in a human breast cancer model with pathological correlation. Eur Radiol, 23(8): 2079-2086. [DOI:10.1007/s00330-013-2828-8] [PMID]
23. Youk JH, Gweon HM, Son EJ, Kim J-A, Jeong J (2013) Shear-wave elastography of invasive breast cancer: correlation between quantitative mean elasticity value and immunohistochemical profile. Breast Cancer Res Treat, 138(1): 119-126. [DOI:10.1007/s10549-013-2407-3] [PMID]
24. Park SY, Choi JS, Han B-K, Ko EY, Ko ES (2017) Shear wave elastography in the diagnosis of breast non-mass lesions: factors associated with false negative and false positive results. Eur Radiol, 27(9): 3788-3798. [DOI:10.1007/s00330-017-4763-6] [PMID]
25. Sadigh G, Carlos RC, Neal CH, Wojcinski S, Dwamena BA (2013) Impact of breast mass size on accuracy of ultrasound elastography vs. conventional B-mode ultrasound: a meta-analysis of individual participants. Eur Radiol, 23(4): 1006-1014. [DOI:10.1007/s00330-012-2682-0] [PMID]
26. Bayat M, Denis M, Gregory A, Mehrmohammadi M, Kumar V, Meixner D, et al. (2017) Diagnostic features of quantitative comb-push shear elastography for breast lesion differentiation. PloS One, 12(3): e0172801. [DOI:10.1371/journal.pone.0172801] [PMID] []
27. Hari S, Paul SB, Vidyasagar R, Dhamija E, Adarsh AD, Thulkar S, et al. (2018) Breast mass characterization using shear wave elastography and ultrasound. Diagn Interv Imag, 99(11): 699-707. [DOI:10.1016/j.diii.2018.06.002] [PMID]
28. Vicini FA, Cecchini RS, White JR, Arthur DW, Julian TB, Rabinovitch RA, et al. (2019) Long-term primary results of accelerated partial breast irradiation after breast-conserving surgery for early-stage breast cancer: a randomised, phase 3, equivalence trial. Lancet, 394(10215): 2155-2164. [DOI:10.1016/S0140-6736(19)32514-0]
29. Martelotto LG, Ng CKY, Piscuoglio S, Weigelt B, Reis-Filho JS (2014) Breast cancer intra-tumor heterogeneity. Breast Cancer Res, 16(3): 210. [DOI:10.1186/bcr3658] [PMID] []
30. Gweon HM, Youk JH, Son EJ, Kim J-A (2013) Visually assessed colour overlay features in shear-wave elastography for breast masses: quantification and diagnostic performance. Eur Radiol, 23(3): 658-663. [DOI:10.1007/s00330-012-2647-3] [PMID]
31. Tian J, Liu Q, Wang X, Xing P, Yang Z, Wu C (2017) Application of 3D and 2D quantitative shear wave elastography (SWE) to differentiate between benign and malignant breast masses. Sci Rep, 7(1): 41216. [DOI:10.1038/srep41216] [PMID] []
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Qu W, He N, Yang X, Yuan C, Zhang G, Wei J et al . Influence of lesion size on differential diagnosis of benign and malignant breast lesions by real-time two-dimensional shear wave elastography. Int J Radiat Res 2022; 20 (3) :607-613
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Volume 20, Issue 3 (7-2022) Back to browse issues page
International Journal of Radiation Research
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