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The effect of patients’ body mass indices on PET/CT images with 68Ga-labeled prostate-specific membrane antigen on a TruFlight PET/CT system
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| Y. Parlak, G. Mutevelizade, C. Sezgin, D. Goksoy, G. Gumuser, E. Sayit |
| Department of Nuclear Medicine, Manisa, Turkey , yasemin.gultekin@hotmail.com |
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Abstract: (214 Views) |
Background: The aim of our study was to determine the appropriate scanning time for 68Ga-labeled PSMA PET/CT imaging by using the BMI of the patients. Materials and Methods: Fifty-seven patients who were included to the study were divided into 4 groups according to their BMI. In addition to the routine imaging protocol, further imaging focused on the patient’s liver was performed. PET images were reconstructed from the reference image obtained for the images at 60, 90, 120, 180, 240, and 300 s/bp. To evaluate PET/CT with 68Ga-PSMA image quality, SNRnorm was calculated using the SNR in the liver. The correlations and differences between scanning times according to BMI were calculated. Results: The SUVmax values of the reconstructed images were obtained and the changes observed in SUVmax were statistically significant (p<0.05). Our results showed that the SUVmax in the liver decreases with increasing scan time. We calculated that SNR decreased with scan time in all groups. The SNR difference was statistically significant only for 60 and 90 s/bp (p=0.045, p=0.02, respectively). No difference in SNRnorm values was determined between the groups (p≥0.05). Conclusion: If the same amount of radioactivity is injected into patients, the liver SUVmax of the overweight patient would be expected to be higher than underweights. Since SUV calculations are standardized according to body weight, BMI and body composition may cause variability in SUV measurements. As the BMI increased, the background activity in 68Ga-PSMA PET/CT images improved. However, due to the longer imaging time, patient movement should be considered. |
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| Keywords: 68Ga PSMA, PET/CT, Imaging Quality, SNR. |
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Full-Text [PDF 813 kb]
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Type of Study: Original Research |
Subject:
Radiation Biology
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