Background: Malignant melanoma of the primary parotid gland (PGMM) is extremely rare, and most of the previous reports are case reports. This study describes the clinical and histological characteristics of a single case of PGMM. Materials and methods: The patient was diagnosed following the detection of a mass in the parotid region. Examination of the resected tissue specimens demonstrated cells with copious eosinophilic cytoplasm, significant pleomorphic in the nuclei, and distinct nucleoli. Immunohistochemical analysis was performed to measure HMB45, S-100, SOX-10, and Melan-A markers expression in tumor tissue. The clinicopathological features of a series of parotid gland malignant melanomas were analyzed. Results: Despite undergoing surgical intervention, immunotherapy, and targeted therapy, this case occurred distant metastases. The patient survived 2 years and 3 months after surgery due to multiple metastases throughout the body. Conclusion: This article reported the clinical characteristics of the case and provided an overview of primary PGMM cases documented over the last three decades.