1. Hsiao KY, Yeh SA, Chang CC, et al. (2010) Cognitive function before and after intensity-modulated radiation therapy in patients with nasopharyngeal carcinoma: a prospective study. Int J Radiat Oncol Biol Phys, 77(3): 722-726. [ DOI:10.1016/j.ijrobp.2009.06.080] 2. Cheung MC, Chan AS, Law SC, et al. (2000) Cognitive function of nasopharyngeal carcinoma patients with and without temporal lobe necrosis after radiotherapy. Arch Neurol, 57(9):1347-1352. [ DOI:10.1001/archneur.57.9.1347] 3. Zer A, Boehmer L, Palzkill T, et al. (2018) Neurocognitive deficits after radiotherapy or chemoradiotherapy in head and neck cancer survivors. JAMA Otolaryngol Head Neck Surg, 144(1):71-79. [ DOI:10.1001/jamaoto.2017.2235] 4. Welsh LC, Dunlop A, McGovern T, et al. (2014) Neurocognitive function following (chemo)radiotherapy for head and neck cancer. Clin Oncol, 26(12):765-775. [ DOI:10.1016/j.clon.2014.06.014] 5. Iyizoba-Ebozue Z, Prestwich R, Brown S, et al. (2023) Neurocognitive function following (chemo)radiotherapy for nasopharyngeal cancer and other head and neck cancers: A systematic review. Radiother Oncol, 188:109863. [ DOI:10.1016/j.radonc.2023.109863] 6. Voon NS, Abdul Manan H, Yahya N (2021) Cognitive Decline following Radiotherapy of Head and Neck Cancer: Systematic Review and Meta-Analysis of MRI Correlates. Cancers (Basel), 13(24): 6191. [ DOI:10.3390/cancers13246191] 7. Wickborn K, van der Weijden CWJ, de Vries EFJ, et al. (2024) Timeline of cognitive impairments after radiotherapy for head and neck cancer: A review. Clin Transl Radiat Oncol, 52: 100890. [ DOI:10.1016/j.ctro.2024.100890] 8. Vaassen F, Hofstede D, Zegers CML, et al. (2025) The effect of radiation dose to the brain on early self-reported cognitive function in brain and head-and-neck cancer patients. Clin Transl Radiat Oncol, 52: 100929. [ DOI:10.1016/j.ctro.2025.100929] 9. Liu P, Niu X, Ou D, et al. (2020) Dynamic changes in cognitive function in patients with radiation-induced temporal lobe necrosis after IMRT for nasopharyngeal cancer. Front Oncol, 10: 450. [ DOI:10.3389/fonc.2020.00450] 10. Williams AM, Lindholm J, Cook D, et al. (2017) Association between cognitive function and quality of life in patients with head and neck cancer. JAMA Otolaryngol Head Neck Surg, 143(12): 1228-1235. [ DOI:10.1001/jamaoto.2017.2014] 11. Sta Maria MT, Hasegawa Y, Khaing AMM, et al. (2023) The relationships between mastication and cognitive function: A systematic review and meta-analysis. Jpn Dent Sci Rev, 59: 375-388. [ DOI:10.1016/j.jdsr.2023.10.001] 12. Li L, Zhang X, Zhang Z, et al. (2023) Tooth loss and the risk of cognitive decline and dementia: A meta-analysis of cohort studies. Front Neurol, 14: 1103052. [ DOI:10.3389/fneur.2023.1103052] 13. Qi X, Zhu Z, Plassman BL, et al. (2021) Dose-response meta-analysis on tooth loss with the risk of cognitive impairment and dementia. J Am Med Dir Assoc, 22(10): 2039-2045. [ DOI:10.1016/j.jamda.2021.05.009] 14. Piancino MG, Tortarolo A, Polimeni A, et al. (2020) Altered mastication adversely impacts morpho-functional features of the hippocampus: A systematic review on animal studies in three different experimental conditions involving the masticatory function. PLoS One, 15(8): e0237872. [ DOI:10.1371/journal.pone.0237872] 15. Krishnamoorthy G, Narayana AI, Balkrishanan D. (2018) Mastication as a tool to prevent cognitive dysfunctions. Jpn Dent Sci Rev, 54(4): 169-173. [ DOI:10.1016/j.jdsr.2018.06.001] 16. Asher S, Glick M, Ship JA (2022) Periodontal health, cognitive decline, and dementia: A systematic review and meta-analysis of longitudinal studies. J Am Geriatr Soc, 70(9): 2695-2709. [ DOI:10.1111/jgs.17978] 17. Nagatani M, Tanaka T, Son BK, et al. (2023). Oral frailty as a risk factor for mild cognitive impairment in community-dwelling older adults: Kashiwa study. Exp Gerontol, 172: 112075. [ DOI:10.1016/j.exger.2022.112075] 18. Parisius KGH, Wartewig E, Schoonmade LJ, et al. (2022). Oral frailty dissected and conceptualized: a scoping review. Arch Gerontol Geriatr, 100: 104653. [ DOI:10.1016/j.archger.2022.104653] 19. Schimmel M, Katsoulis J, Genton L, Müller F (2023). Assessment and improvement of masticatory performance in older adults. Int J Environ Res Public Health, 20(4): 3214. 20. Zhao H, Liu J, Sun W, Wang M, Li Z, et al. (2024). Oral frailty: a concept analysis. BMC Oral Health, 24: 43. [ DOI:10.1186/s12903-024-04376-6] 21. Foo WT, Chia JL, Yap P (2025) Oral frailty and outcomes: A scoping review. Proc Singap Healthc, 35. [ DOI:10.1177/20101058251355290] 22. Dibello V, Zupo R, Sardone R, et al. (2021) Oral frailty and its determinants in older age: a systematic review. Lancet Healthy Longev. 2(8): e507-e520. [ DOI:10.1016/S2666-7568(21)00143-4] 23. Cristofaro MG, Barca I, Ferragina F, et al. (2021) The health risks of dysphagia for patients with head and neck cancer: a multicentre prospective observational study. J Transl Med, 19(1): 472. [ DOI:10.1186/s12967-021-03144-2] 24. Kristensen MB, Isenring E, Brown B (2020) Nutrition and swallowing therapy strategies for patients with head and neck cancer. Nutrition, 69: 110548. [ DOI:10.1016/j.nut.2019.06.028] 25. Matko S, Knauseder C, Riedl D, et al. (2025) The role of dysphagia on head and neck cancer patients' quality of life, functional disabilities and psychological distress: Outcomes of cancer rehabilitation from an observational single-center study. Curr Oncol, 32: 220. [ DOI:10.3390/curroncol32040220] 26. Wang K, Pearlstein KA, Moon DH, et al. (2019) Xerostomia, parotid dose, and patient outcomes after radiotherapy. JAMA Oncol, 5(2): 221-228. [ DOI:10.1001/jamaoncol.2018.4951] 27. Wu Z, Han Y, Wan Y, et al. (2023) Oral microbiome and risk of incident head and neck cancer: A nested case-control study. Oral Oncol, 137: 106305. [ DOI:10.1016/j.oraloncology.2022.106305] 28. Memtsa PT, Tolia M, Tzitzikas I, et al. (2017) Assessment of xerostomia and its impact on quality of life in head and neck cancer patients undergoing radiation therapy. Mol Clin Oncol, 6(5): 789-793. [ DOI:10.3892/mco.2017.1200] 29. Gondi V, Pugh SL, Tome WA, et al. (2014) Preservation of memory with conformal avoidance of the hippocampal neural stem-cell compartment during whole-brain radiotherapy for brain metastases (RTOG 0933): a phase II multi-institutional trial. J Clin Oncol, 32(34): 3810-3816. [ DOI:10.1200/JCO.2014.57.2909] 30. Suh JH (2014) Hippocampal-avoidance whole-brain radiation therapy: a new standard for patients with brain metastases? J Clin Oncol, 32(34): 3789-91. [ DOI:10.1200/JCO.2014.58.4367] 31. Perlow HK, Nalin AP, Ritter AR, et al. (2024) Advancing beyond the hippocampus to preserve cognition for patients with brain metastases: Dosimetric results from a phase 2 trial of memory-avoidance whole brain radiation therapy. Adv Radiat Oncol, 9(2): 101337. [ DOI:10.1016/j.adro.2023.101337] 32. Abraham CD, Pugh SL, Bovi JA, et al. (2022) Association of pretreatment hippocampal volume with neurocognitive function in patients treated with hippocampal-avoidance whole brain radiation therapy for brain metastases: secondary analysis of NRG Oncology/RTOG 0933. Adv Radiat Oncol, 7(6): 100859. [ DOI:10.1016/j.adro.2021.100859] 33. Mehta MP, RTOG 0933 Investigators (2011) Protocol for hippocampal avoidance in whole brain radiotherapy (RTOG 0933). Clinical Trial Protocol. 34. yizoba-Ebozue Z, Prestwich R, Brown S, et al. (2023) Neurocognitive function following (chemo)radiotherapy for nasopharyngeal cancer and other head and neck cancers: a systematic review. Radiother Oncol, 188: 109863 [ DOI:10.1016/j.radonc.2023.109863] 35. Noor A, Ganti AK, Shafique K, et al. (2018) Frailty in geriatric head and neck cancer: a contemporary review. Laryngoscope, 128(12): E416-E424. [ DOI:10.1002/lary.27339] 36. Giannotti C, Porceddu S, Corcoran N, et al. (2024) Frailty and survival in older patients undergoing radiotherapy for head and neck squamous cell carcinoma: a prospective analysis. Cancers, 16(23): 3939. [ DOI:10.3390/cancers16233939] 37. Mady LJ, Baddour K, Hodges JC, et al. (2022) The impact of frailty on mortality in non-surgical head and neck cancer treatment: shifting the clinical paradigm. Oral Oncol, 126: 105766. [ DOI:10.1016/j.oraloncology.2022.105766] 38. Keenan LG, O'Brien M, Ryan T, et al. (2023) Assessment of older patients with cancer: Edmonton Frail Scale (EFS) as a predictor of adverse outcomes in older patients undergoing radiotherapy. J Geriatr Oncol. 8(3): 206-210. [ DOI:10.1016/j.jgo.2016.12.006] 39. Røyset IM, Eriksen GF, Benth JŠ, et al. (2023) Edmonton Frail Scale predicts mortality in older patients with cancer undergoing radiotherapy. PLoS One. 18(3): e0283507. [ DOI:10.1371/journal.pone.0283507] 40. De Schrevel J, Faucon C, Sibille FX, et al. (2024). The Edmonton Frail Scale as a screening score for frailty in oncogeriatrics. Frontiers in medicine, 11: 1466366. [ DOI:10.3389/fmed.2024.1466366] 41. Page MJ, McKenzie JE, Bossuyt PM, et al. (2021) The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ, 372: n71. [ DOI:10.1136/bmj.n71] 42. Page MJ, Moher D, Bossuyt PM, et al. (2021) PRISMA 2020 explanation and elaboration: updated guidance and exemplars for reporting systematic reviews. BMJ, 372: n160. [ DOI:10.1136/bmj.n160] 43. Stroup DF, Berlin JA, Morton SC, et al. (2000) Meta-analysis of observational studies in epidemiology: a proposal for reporting. JAMA, 283(15): 2008-2012. [ DOI:10.1001/jama.283.15.2008] 44. Brooke BS, Schwartz TA, Pawlik TM (2021) MOOSE reporting guidelines for meta-analyses of observational studies. JAMA Surg, 156(8): 787-788. [ DOI:10.1001/jamasurg.2021.0522] 45. Guyatt GH, Oxman AD, Vist GE, et al. (2011) GRADE guidelines: 1. Introduction - GRADE evidence profiles and summary of findings tables. J Clin Epidemiol, 64(4): 383-394. [ DOI:10.1016/j.jclinepi.2010.04.026] 46. Guyatt GH, Oxman AD, Kunz R, et al. (2008) GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. BMJ, 336(7650): 924-926. [ DOI:10.1136/bmj.39489.470347.AD] 47. Mireștean CC, Buzea CG, Zară AD, et al. (2025) Potential risk of cognitive impairment due to irradiation of neural structures in locally advanced nasopharyngeal cancer treated by curative radiotherapy. Medicina. 61(5): 810. [ DOI:10.3390/medicina61050810] 48. Li PJ and Chen YY (2020) Narrative review: temporal lobe necrosis after radiotherapy for nasopharyngeal carcinoma. Ann Nasopharynx Cancer, 4: 10. [ DOI:10.21037/anpc-2019-LCMNC-03] 49. Kitpanit S, Thamruangporn P, Teyateeti A, et al. (2020) Temporal lobe necrosis in head and neck cancer patients after proton therapy to the skull base. Int J Part Ther, 6(4): 17-28. [ DOI:10.14338/IJPT-20-00014.1] 50. Williams AM, Lindholm J, Siddiqui F, et al. (2017) Clinical assessment of cognitive function in patients with head and neck cancer: prevalence and correlates. Otolaryngol Head Neck Surg, 157(5): 808-815. [ DOI:10.1177/0194599817709235]
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