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Diagnostic performance and safety of ultrasound-guided core-needle biopsy for suspicious malignant lymphadenopathy in oncologic staging: A single-center study
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L. Wang   , W. Zhao , W. Shi , N. An , S. Zhang |
| Shanxi Provincial People's Hospital(The Fifth Clinical Medical College of Shanxi Medical University), Shanxi Medical University, Taiyuan, China , 17635306222@163.com |
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Abstract: (15 Views) |
Background: Pathological confirmation of suspicious lymphadenopathy is essential for oncologic staging and treatment planning. This study evaluated the diagnostic performance and safety of a standardized ultrasound-guided core-needle biopsy (CNB) protocol for suspicious malignant lymphadenopathy. Materials and Methods: This single-center diagnostic accuracy study included 328 adults who underwent ultrasound-guided core-needle biopsy (CNB) at Yangquan First People's Hospital between January 2021 and June 2023. A standardized workflow was used for ultrasound assessment, route planning, real-time Doppler-assisted guidance, specimen handling, and postprocedural surveillance. Saline-assisted hydrodissection was applied for vascular-adjacent lymph nodes. Final diagnosis was established using surgical pathology, repeat biopsy, immunohistochemistry, microbiological confirmation, or at least 6-month clinical/imaging follow-up. Results: Technical success was achieved in 317 of 328 patients (96.6%). Among technically successful cases, 175 malignant and 142 benign lesions were identified. Diagnostic accuracy was 95.9% (304/317), sensitivity 96.6% (169/175), specificity 95.1% (135/142), positive predictive value 96.0% (169/176), and negative predictive value 95.7% (135/141). The area under the receiver operating characteristic curve was 0.983 (95% confidence interval [CI], 0.972-0.994). Complications occurred in 14 patients (4.4%), with no severe adverse event. Conclusion: Standardized ultrasound-guided CNB is a safe and accurate minimally invasive approach for suspicious malignant lymphadenopathy and can support pathological confirmation for oncologic staging and treatment decision-making. |
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| Keywords: Ultrasonography, biopsy, large-core needle, lymph nodes, neoplasm staging, safety. |
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Full-Text [PDF 1004 kb]
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Type of Study: Original Research |
Subject:
Radiation Biology
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