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AWT IMAGE

AWT IMAGE

:: Volume 9, Issue 4 (3-2012) ::
Int J Radiat Res 2012, 9(4): 209-219 Back to browse issues page
FDG-PET/MRI fused data sets for the detection of liver metastases in patients undergoing systemic anticancer treatment
T.A. Heusner , C. Mikat , S. Hahn , J. Altenbernd , A. Stahl , A. Bockisch , M. Forsting , G. Antoch
, Heusner@med.uni-duesseldorf.de
Abstract:   (11475 Views)
Background: To retrospectively describe imaging characteristics of liver metastases on fused FDG-PET/ MRI data sets and to compare the diagnostic accuracy of MRI and fused FDG-PET/MRI data sets for the detection of liver metastases in patients undergoing systemic anticancer treatment. Materials and Methods: 43 oncological patients (mean age: 56+/- 11 years) were investigated by FDG-PET/CT and liver MRI. FDG-PET data from PET/CT scans were fused with MRI. 556 lesions were evaluated. 5 different evaluation algorithms were used for FDG-PET/ MRI evaluation. The sensitivity, specifity, PPV, NPV and accuracy of MRI and FDG-PET/MRI data for the detection of liver metastases were calculated. A mean follow-up of 647 days served as reference standard. McNemar’s test was used to test for statistically significant differences between MRI and FDG-PET/MRI (p<0.5). Results: The sensitivity, specificity, PPV, NPV and accuracy of MRI for the detection of liver metastases were 86%, 81%, 97%, 47%, and 85% and 50%, 100%, 100%, 22%, and 56%, for FDGPET/ MRI. FDG-PET/MRI was significantly less accurate than MRI alone (p<.001). Conclusion: In opposite to patients before systemic anticancer therapy the fusion of FDG-PET data with liver MRI cannot be recommended for the detection of liver metastases in patients undergoing systemic oncological therapy. Iran. J. Radiat. Res., 2012 9(4): 209-219
Keywords: PET/MRI, PET/CT, liver MRI, liver metastases, hybrid imaging
Full-Text [PDF 400 kb]   (2540 Downloads)    
Type of Study: Original Research | Subject: Radiation Biology
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Heusner T, Mikat C, Hahn S, Altenbernd J, Stahl A, Bockisch A, et al . FDG-PET/MRI fused data sets for the detection of liver metastases in patients undergoing systemic anticancer treatment. Int J Radiat Res 2012; 9 (4) :209-219
URL: http://ijrr.com/article-1-814-en.html


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Volume 9, Issue 4 (3-2012) Back to browse issues page
International Journal of Radiation Research
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