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Assessment of metrezoate-labeled gallium transmission in cultured human Burkitt lymphatic cells
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M. Navvabpour   , H. Moladoust , N. Navvabpour |
| , hmoladoust@gums.ac.ir |
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Abstract: (9580 Views) |
| Background: In addition to determining the exact
tumor location and its geometric features, an
increase of the effective tumor atomic number will
enhances the chance in treating the tumoral cells
under suitable radiation. In the present study, we
assessed metrezoate-labeled gallium transmission in
Burkett lymphatic cells. Materials and Methods:
Human Burkitt lymphatic cells were grown in culture
media. Metrezoate-76% labeled with gallium-67 and
the developed complex was used with a volumetric
amount of 125%. The complex was added to the
culture media, and then the absorbed volume was
determined. Through the SPECT imaging system, the
culture media containing the lymphatic cell colonies
were scanned 1, 2, 4, 8, 24, 48, and 72-hr postaddition
of metrezoate-gallium complex. The transmitted
activities in the colonies area were measured
after imaging. Results: Gallium-metrezoate complex
is significantly accumulated in malignant lymphatic
cells. The study of the results throughout 72-hr
revealed that most absorption, count quantity and
transmitted activity had all occurred 4-hr after adding
gallium-metrezoate complex solution. Conclusion: It
can be concluded that gallium-metrezoate complex
can be significantly accumulated in the Burkett
lymphatic cells and uptake is non-linear with
exposures time. This method of enhancing effective
atomic number in malignant lymphatic cells therefore
appears promising. Iran. J. Radiat. Res., 2012 10(2):
99‐104
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| Keywords: Effective atomic number, lymphatic tumoral cells, gallium-metrezoate |
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Full-Text [PDF 215 kb]
(1775 Downloads)
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Type of Study: Original Research |
Subject:
Radiation Biology
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