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Showing 3 results for Araz
S.j. Hosseinimehr, Dr. D. Beiki, A. Kebriaeezadeh, A. Khalaj, M. Pirali Hamedani, Sh. Akhlaghpoor, H. Esmaeili, A.r. Barazesh,
Volume 7, Issue 2 (9-2009)
Abstract
Background: The aim of this study was to evaluate the radioprotective capacity of some novel aminoalkylated dithiocarbamic acid potassium salts against γ-irradiation in mice. Materials and Methods: Eight compounds containing 2-aminoethyl-, 3- aminopropyl-, 4-aminobutyl-, 5-aminopentyl-, 6- aminohexyl-, 7-aminoheptyl-, 8-aminooctyl and 9- aminononyl of dithiocarbamate derivatives were prepared. Male NMRI mice were injected intraperitoneally (IP) with a geometric progression of doses (300 -1000 mg/kg), through the dose response range for lethal toxicity. To evaluate the radioprotecive activity, one-half of the toxic LD50 of each compound were injected IP to groups of twenty mice, 30 minutes prior to γ-irradiation. The treated animals were kept for 30 days, and the lethality was recorded each day. Results: Among Eight compounds of alkyl dithiocarbamic acid derivatives, 5-aminopentyl, 7-aminoheptyl, 8-aminooctyl and 9-aminononyl dithiocarbamic acid mono potassium salts are new compounds. All evaluated compounds showed a concentrationdependent effect on the survival in mice. The LD50 values were found to be more than 599 mg/kg. The percentages of 30-day survival of mice for 2- aminoethyl, 7-aminoheptyl and 8-aminooctyl dithiocarbamic acid derivatives were 7%, 40% and 13.5%, respectively, when injected 30 minutes before γ- irradiation. Other compounds had no radioprotective effects. Statistical analysis showed a significant difference between the treated and control groups for the 7-aminoheptyl derivative (p<0.05). Conclusion: Among the compounds investigated in this study, 7- aminoheptyl dithiocarbamate derivative showed more radioprotective effects in comparison with the others. Although it seems that the radioprotective effects in these derivatives correlate with the size of the alkyl chain, more experiments are required to support this hypothesis. Iran. J. Radiat. Res., 2009 7 (2): 91-96
Dr. G. Yavas, M. Araz, C. Yavas, F. Baba, O. Ata,
Volume 11, Issue 3 (7-2013)
Abstract
After curative treatment of Hodgkin’s lymphoma, increased risk of certain solid tumors has been reported. To best of our knowledge this is the first report of metachronous pancreatic adenocarcinoma which developed outside the previous radiation field in a patient with relapse Hodgkin’s lymphoma. Herein we present an 81-year-old female who developed pancreatic adenocarcinoma four years after the curative treatment of Hodgkin’s lymphoma.
M. Haghani, Phd., K. Haddad, Phd., S.m.j. Mortazavi, R. Faghihi, A. Pirouzmand, M. Faraz,
Volume 18, Issue 1 (1-2020)
Abstract
Background: Indoor levels of 222Rn in some residential areas in Ramsar are as high as 31,000 Bq/m3, resulting in mean internal exposures up to 71 mSv/y. The main goal of this study was to develop a simple mathematical model for predicting radon concentrationfrom gamma radiation level in dwellings located in high background radiation areas (HBRAs) and a nearby normal background radiation area (NBRA) of Ramsar. Materials and Methods: The levels of gamma background radiation and indoor radon were measured in 350 dwellings located in normal and high background radiation areas (210 dwellings from HBRAs and 140 dwellings from NBRAs). Moreover, data about the most important environmental factors such as temperature and humidity as well as the inhabitants’ nutrition were collected. Results: The mathematical relationship between the gamma radiation level and indoor radon concentration in NBRAs and HBRAs is introduced in this study. The findings obtained in this study clearly indicate that in normal and high background radiation areas of Ramsar the majority of confounding factors such as the type of building materials and ventilation in different houses are almost identical. Therefore, the level of gamma radiation can be used as a strong predictive tool for radon concentration. Conclusion: As radon concentration in indoor air strongly varies with time, the simple mathematical methods developed in this study, can help health physicists and environmental scientists have an estimate of the mean radon level in these areas.
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