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Showing 15 results for Cai
Md, F. Huang, J.g. Ye, L.b. Su, Y.y. Guo, W.x. Liu, C. Cai,
Volume 17, Issue 3 (6-2019)
Abstract
Background: This study assessed the application value of 64-slice spiral computed tomography angiography (CTA) in a follow-up evaluation of patients receiving coronary stent implantation. Materials and Methods: A total of 468 patients who underwent percutaneous coronary intervention (PCI) at our hospital between January 2013 and October 2016 were selected for this study. Coronary angiography and 64-slice spiral coronary CTA were performed. The differences between CTA and coronary angiography regarding the diagnosis of in-stent restenosis (ISR) were compared. Results: The sensitivity, specificity, false positive rate, false negative rate, positive predictive value, negative predictive value, and accuracy of 64-slice spiral coronary CTA in evaluating ISR were 77.9%, 96.4%, 3.6%, 22.1%, 69.1%, 97.7%, and 94.71%, respectively. The results of the CTA and coronary angiography in diagnosing ISR in different locations of the coronary artery were not significantly different (P>0.05). CTA imaging quality was significantly better for stents with diameters >3 mm than that for stents with diameters ≤3 mm (P<0.05). Conclusion: Overall, 64-slice spiral coronary CTA has very high accuracy and was not significantly different compared with coronary angiography when assessing the patency of stents. CTA is advantageous because it is inexpensive, simple and convenient, and it can be used for follow-up examinations.
H. Wang, H. Chen, Y. Shao, J.m. Wang, J.d. Guo, X.w. Cai, X.i. Fu, Prof. Z.y. Xu,
Volume 18, Issue 3 (7-2020)
Abstract
Background: The pattern of interfractional tumor changes during limited disease small-cell lung cancer (LD-SCLC) radiotherapy is not clear, The study was to evaluate tumor changes based on interfractional CBCT images and it’s impact on dosimetry. Material and Method: We analyzed tumor changes and it’s dosimetry impact for 30 LD-SCLC patients who were treated with concurrent chemoradiotherapy(cCRT). CBCT images were acquired for each patient every five fractions before each treatment. The grass tumor volume(GTV) and total lung were adapted to create the GTVn and total lungn based on CBCTn. Dose was recalculated for every CBCT fraction. The impact on target dose coverage and lung sparing was also evaluated while relevant tissue's CT density correction was done on plan CT combined with tumor changes adapted by fraction’s CBCT images. Results: Mean GTV volume of each CBCT fraction reduced，and mean GTV volume of 7th CBCT fraction shrank nearly 10% compared to 1st fraction. The centroid positions of left/right tumors moved towards the right/left direction gradually. Most left/right tumor borders had a trend of rightward/leftward shrinkage. Target dose coverage and lung tissue dose volume increased through fractions. CT image density correction slightly increased the target dose coverage and lung tissue dose volume. Conclusion: Tumor shrinkage was seen for LD-SCLC patients, it’s related to the tumor's initial volume and location. It is appropriate that most LD-SCLC patients should be intervened at 21st radiotherapy fraction.
X. Hu, C. Peng, C. Yang, J. Zheng, Ms.c., P. Wang, Ph.d., J. Cai,
Volume 20, Issue 2 (4-2022)
Abstract
Background: Ewing's sarcoma/primary neuroectodermal tumors (EWs/PNETs) originating in the kidney have been rarely reported. To date, EWs/PNETs have not been demonstrated to have specific clinical characteristics and imaging findings. Case Presentation: A 13-year-old boy was admitted to the hospital with abdominal pain following minor trauma. The patient underwent CT examination on the doctor's recommendation, which revealed contusion of the left kidney and the possibility of a space-occupying lesion in the lower pole of the left kidney. Hence, laparotomy was performed at our hospital, followed by excision of the left kidney, tumor detection and removal of hematoma. The pathological diagnosis was left kidney EWs/PNET with hemorrhagic infarction. Postoperatively, the patient did not receive radiotherapy or chemotherapy. After three months, the patient returned to the hospital for Positron Emission Topography (PET)/CT examination, and no obvious signs of tumor recurrence and metastasis were found all over the body. To date, the patient has been followed-up for 15 months, and remains alive and healthy. Conclusion: EWs/PNETs are highly invasive tumors, with frequent distant metastasis at diagnosis. Hence, early diagnosis and surgical removal of tumor tissue is critical for the prognosis of patients. CT can be used as the primary auxiliary examination of primary renal EWs/PNET. Cystic necrosis is found in the tumor tissue on the CT image. Moreover, cystic necrosis located around the tumor and septal enhancement are observed on the CT enhanced scan, which is helpful for the diagnosis of primary renal EWs/PNET.
Y. Li, F. Pang, H. Cai, M.d., L. Li,
Volume 20, Issue 4 (10-2022)
Abstract
Background: Our aims were to prepare microspheres labelled with radioactive astatine as brachytherapy seeds and to confirm the antitumor ability of these microspheres. Materials and Methods: Chitosan-collagen composite microspheres (CCMs) were synthesized through an emulsification crosslink reaction and radiolabelled with 211At using the chloramine-T method. Radiation stability was assessed in both phosphate-buffered saline and blood serum. The in vivo distribution and therapeutic effects were evaluated in BALB/c nude mice with implanted tumours. Results: CCMs showed ideal morphological characteristics (diameter of 7.5-15 μm) and acceptable radiation stability (73.99% in PBS and 72.56% in serum after 16 hours). The in vivo biodistribution analysis demonstrated that 211At-CCMs were highly localized in tumour tissue. The therapeutic efficacy of 211At-CCMs when intratumorally injected into a cervical tumour model was assessed. Fourteen days after a single-dose treatment with 211At-CCMs, significantly retarded tumour volume growth was observed. Conclusion: 211At-CCM brachytherapy has the potential to provide an alternative solution for tumour treatment.
X. Hu, H. Hu, R. Yu, X. Cai, P. Yang, Ph.d., J. Cai,
Volume 20, Issue 4 (10-2022)
Abstract
Natural Cat scratch disease is caused by the infection of Bartonella henselae after a cat scratch, bite, or close contact, and mainly presents with skin lesions and swollen lymph nodes in the drainage area. Herein, we report a 71-year-old female cat scratch disease patient who initially presented with low fever and enlarged lymph nodes on the left side of her neck, who underwent fluorine-18 labeled fluorodeoxyglucose positron emission tomography/computed tomography for suspected lymphoma. As increased fluorodeoxyglucose uptake can indicate inflammation or tumor, and lymph node enlargement accompanied by abnormal metabolism can mimic lymphoma or other diseases, the diagnosis of cat scratch disease is difficult. Its diagnosis should be indicated when unilateral lymphadenopathy is accompanied by abnormally high metabolic uptake of fluorodeoxyglucose.
X. Hu, C. Zhang, K. Qian, R. Yu, T. Mei, Ph.d., J. Cai,
Volume 20, Issue 4 (10-2022)
Abstract
Background: Epithelioid sarcoma (ES) is a rare soft tissue tumor that mainly occurs under the skin of the extremities. ES in the groin area may be easily misdiagnosed with undifferentiated pleomorphic sarcoma, leiomyosarcoma, rhabdomyosarcoma, and other mesenchymal tumors. Herein, we reported a single case of a patient with proximal-type epithelioid sarcoma of the groin, including its clinical and imaging findings. We also discussed some previously reported similar cases. Case Presentation: Our ES patient was a 24-year-old male who developed a subcutaneous nodule in the groin area 1 year before admission. After careful clinical and pathological examination, the patient was diagnosed with ES. He received chemotherapy (doxorubicin, ifosfamide plus cisplatin) and, later on, surgery. His symptoms improved, and he is still being followed up. In addition, we conducted a review of the literature and compared our data with 12 previously reported similar cases (including 17 patients with ES involving the groin). Conclusion: ES is a highly invasive tumor prone to metastasis and postoperative recurrence. Surgery seems to be the most effective treatment for ES. The effectiveness of auxiliary and radiotherapy needs to be confirmed by a large amount of data. A systematic understanding of the clinical and imaging features of ES in the groin area may help clinical and imaging doctors to correctly diagnose the disease.
R. Li, J. Cai, Y. Wang, C. Fu, Ph.d., B. Hu,
Volume 21, Issue 1 (1-2023)
Abstract
Background: The existence of correlates between radiation and plasma metabolites in rats might be affected by feeding conditions. Materials and Methods: The rats were kept without food and water for a certain time before the blood was harvested on the seventh day after X-ray irradiation at doses of 0 and 8 Gy. The plasma metabolites were tested using Enzyme-Linked Immunosorbent Assay (ELISA). Results: Our results showed that abrosia for 2 h before blood harvesting could increase the level of detections of both interleukin-6 (IL-6) and glycine (Gly) in rats. Furthermore, abrosia and meanwhile water deprivation for 2-4 h increased better the level of detections of IL-6 and Gly in rats. Conclusion: The level of detections of biomarkers in the blood may be more authentic and can better reflect the changes in the experimental animals after stress when they are treated by both abrosia and water deprivation for 2 h before blood harvesting.
W.g. Feng, W. Ma, Sh.p. Li, Y.x. Guo, W. Du, Ph.d., H.y. Cai,
Volume 21, Issue 3 (7-2023)
Abstract
Background: In recent years, volumetric-modulated arc therapy (VMAT) and fixed field intensity-modulated radiotherapy (IMRT) have been used as the two mainstream radiotherapy techniques for the treatment of nasal tumors. In this study, we compared effectiveness of these two radiotherapy techniques in the treatment of nasal tumors through analysis of relevant literature and meta-analysis. Materials and Methods: A search was performed on PubMed, Web of Science, Embase, and Cochrane Library databases on April 2022 to identify all related literature in line with pre-determined eligibility criteria. The included/excluded studies were screened manually and relevance data were extracted. Forest plots were plotted and analyze, Egger’s asymmetry tests and sensitivity analysis were conducted using software Stata 16.0. Results: Eight studies were included in the meta-analysis. We found no significant difference in D2% and D98% of the Planning Target Volumes (PTV) between VMAT and IMRT. In contrast, the conformity index (CI) and the homogeneity index (HI) were significantly different between the two groups. Further analysis revealed no significant differences in dose sparing for all analyzed organs at risk (OARs) between VMAT and IMRT techniques. In addition, the monitor unit (MUs) of VMAT plan was significantly lower than that of the IMRT plan. Conclusions: VMAT has better local tumor control rate compared with IMRT, but it does not significantly reduce maximum dose (Dmax) or mean dose (Dmean) of OARs. We suggest that VMAT plan may be a better radiation therapy technology in the treatment of nasal tumors.
C.f. Cai, Y. He, D. Yue, Z.h Wang, N. Guo, Ph.d., J. Tian,
Volume 21, Issue 4 (10-2023)
Abstract
Background: To investigate the effect of DIRAS2 on the response to ionizing radiation (IR) and the related potential molecular mechanism in human ccRCC cells. Materials and Methods: In this paper, the expression levels of DIRAS2 in human ccRCC and paired normal tissues were obtained from the Oncomine platform and The Cancer Genome Atlas (TCGA) database, which was further validated by immunohistochemistry. DIRAS2-overexpression cell lines were constructed using a lentivirus-mediated gene expression system. A clonogenic assay was performed to evaluate cell radiation resistance. The effect of DIRAS2 on autophagy was determined by immunoblotting and immunofluorescence analysis. The expression of DIRAS2 and related signalling molecules was evaluated by immunoblotting. Results: Here, we found that the expression of DIRAS2 was upregulated in human ccRCC. Overexpression of DIRAS2 promoted radiation resistance in ccRCC cells and enhanced the levels of radiation-induced autophagy. Moreover, inhibition of autophagy by chloroquine (CQ) pretreatment largely eliminated the effect of DIRAS2 overexpression on radiation resistance. Finally, molecular mechanism investigation showed that DIRAS2 activated the mitogen-activated protein kinase (MAPK) kinase 4 (MKK4)-c-Jun NH2-terminal kinase 1 (JNK1)-Bcl-2 pathway. Conclusion: Taken together, these results indicated that DIRAS2 may confer radiation resistance to human RCC via autophagy induction through the MKK4-JNK1-Bcl-2 signalling pathway.
H. Hu, X. Hu, M.d., D. Li, Ph.d., J. Cai,
Volume 21, Issue 4 (10-2023)
Abstract
Pulmonary cryptococcosis (PC) of the lungs is a fungal infection often occurring in immunocompromised patients, which is most commonly contracted by inhalation. Here, we report the case of a 44-year-old woman who had undergone modified radical surgery for stage I intraductal carcinoma of the left breast one year earlier and had been undergoing endocrine therapy with tamoxifen. Fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) findings indicated multiple pulmonary nodules, which was highly suspicious of lung metastasis from breast cancer. However, the pathological results suggested cryptococcus infection. The patient was subsequently treated with itraconazole antifungal therapy. However, a chest computed tomography (CT) examination one month later revealed that both lung lesions were still present. Her clinician suspected they were due to her intake of the estrogen receptor inhibitor tamoxifen and asked her to stop temporarily taking the drug. One month later, chest CT reexamination revealed that the lung lesions had disappeared. So far, there have been no reports of pulmonary cryptococcosis caused by tamoxifen after breast cancer surgery. Our case study suggests that PC infection may be one of the rare side effects of tamoxifen and should be considered in the differential diagnosis of multiple nodules in both lungs in patients with a history of cancer surgery and taking estrogen receptor inhibitors. Therefore, the etiology of infections should be considered in the differential diagnosis, especially in patients taking estrogen receptor inhibitors after tumor surgery.
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