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Showing 2 results for Dinçer
M.d., G. Alço, T. Ercan, Ş. İğdem, M. Barlan, M. Dinçer, S. Okkan,
Volume 20, Issue 2 (4-2022)
Abstract
Background: To determine the degree of lung inflation sufficient to compensate for cardiac motion in patients receiving standard tangential left-breast radiotherapy during deep inspiration breath hold (DIBH). Materials and Methods: Computed tomography (CT) scans were performed in 20 patients with left-sided early breast cancer during free breathing (FB) and DIBH. Standard tangential field plans were generated in both CT sets. Doses to the organs at risk were assessed. The margin between the left anterior descending artery (LAD) and posterior field edge was measured from the closest point. Results: The DIBH plans showed equal coverage of the breasts, so it was possible to obtain lower cardiac doses with DIBH. The median increase in the left-lung volume with DIBH was 53% (range 12.6% - 108%). A LAD safety distance ≥ 5mm from field edges was not obtained in any of the patients during FB, whereas in 60% of the patients during DIBH the safety distance was obtained. The lung inflation rate and cardiac safety distance were strongly correlated. The mean distance between the LAD and tangential field posterior edge increased significantly from 0.23 cm to 0.64 cm (p=0.041) in the patients who inflated their ipsilateral lung > 1.5 times. Conclusion: Lung inflation of ≥50% compensated for cardiac motion during treatment using DIBH. The lung inflation capacity should be considered in choosing the irradiation technique in left-sided breast cancer patients.
Ph.d., T. Berber, I. Harmankaya, F. Aksaray, Y. Büyükpolat, F. Adatepe, B.d. Yilmaz, S.t. Dinçer, G. Coşgun, Ç. Numanoglu, M.n. Güven, M.e. Gül, C. Yildirim, A.a. Erken,
Volume 20, Issue 3 (7-2022)
Abstract
Background: To elucidate the efficacy and toxicity of brain re-radiotherapy for recurrent large inoperable gliomas using radiosurgery. Materials and Methods: Between 2014 and 2018, extreme hypofractionated radiosurgery was performed using Accuray’s Cyberknife® system on 14 lesions (12 patients) grade 4 recurrence lesions of 6 patients with anaplastic astrocytoma and 6 patients with glioblastoma who had previously undergone surgery and cranial radiotherapy and had a local-regional recurrence. Six patients (8 lesions) were given a biologic effective dose (BED10) of 48 Gy and lower, and six patients were given a BED10 of 59.5 Gy and higher. The Response Assessment in Neuro-Oncology Criteria (RANO) were used for tumor response, and the Common Terminology for Adverse Events (CTCAE) was used for adverse effect assessment. The primary endpoint was determined as overall survival, and first treatment and salvage treatment time. Results: The median age of the patients was 43 years, and the median Karnofsky Performance Status (KPS) was 70. The median time from the first radiotherapy to death was 34 months. The median time from the previous radiotherapy was 29.5 months (R:17-40). The median survival was 10 months for those with recurrence before 29.5 months and 11 months for those with recurrence after 29.5 months. The median total tumor volume was 29.224 mL (~30 mL). One grade 4 toxicity was observed. Conclusion: Radiosurgery can be used effectively as salvage therapy in ultra-large inoperable gliomas.
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