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Showing 4 results for Hui
Dr. Q.m. Rashed-Nizam, M. Rahman, M.k. Tafader, M. Zafar, A.k.m.s.i. Bhuian, R.a. Khan, M. Kamal, M.i. Chowdhury, M.n. Alam,
Volume 14, Issue 4 (10-2016)
Abstract
To assess the environmental radioactivity levels and hence to determine the population exposure in Kutubdia Island, Bangladesh the sediment samples were analyzed by using gamma ray spectrometry. In those sediment samples the average activity concentration of natural radionuclides 238U, 232Th and 40K were found 15.39±1.67, 38.35±0.76 and 475.51±21.15 Bq/kg respectively. The activity concentration of 238U and 232Th were less than the world average. But the activity concentration of 40K was higher than the world average values. These results were used to calculate the radiological hazard parameters like radium equivalent activities (Raeq), representative level index (Iγr). Due to natural radionuclides in sediment, the effective annual outdoor dose in the study area was 0.07 mSv; which is within the accepted range of 0.07 mSv. The average value of radium equivalent activities (Raeq) and representative level index (Igr) were found to be 128.03±12.08 Bq/Kg and 0.96±0.09 Bq/Kg which were greater than the world average. The anthropogenic radionuclide 137Cs was also found in few samples. The average activity concentration of 137Cs was 1.64±0.20 Bq/kg which is lower than the world average. The obtained experimental data of this research work would be useful to assess the population exposure from radionuclides in sediment as well as base line data of natural radioactivity in this island.
F.h.f. Jaffar, K. Osman, C.k. Hui, A.f. Zulkefli, Ph.d., S.f. Ibrahim,
Volume 22, Issue 2 (4-2024)
Abstract
Background: Wireless Fidelity (Wi-Fi) exposure might induce tissue damage through non-thermal effects. Nonetheless, only a few studies have evaluated the non-thermal effects on the testis undergoing reproductive development following Wi-Fi exposure. This study aimed to assess the oxidative stress status in the testis and subsequent sperm quality of growing rat pups that received edible bird nest (EBN) supplementation simultaneously. Materials and Methods: Fourteen weeks of 2. 45GHz Wi-Fi exposure and simultaneous 250mg/kg EBN were supplemented to three-week-old male Sprague–Dawley rats. Thirty animals were divided equally into control, control EBN, Wi-Fi, sham Wi-Fi, and Wi-Fi+EBN. Results: Results showed an increase in total oxidant status (TOS), a significant decrease in total antioxidant status (TAS), and a significant increase in the expression of 8-hydroxy-2′-deoxyguanosine (8-OHdG) in the testis of the Wi-Fi group. Sperm chromatin integrity, morphology, concentration, and motility were among the parameters that significantly decreased. Supplementation of 250mg/kg EBN in the Wi-Fi+EBN group significantly reduced TOS and 8-OHdG expression in the testis. EBN supplementation also significantly increased sperm chromatin integrity, morphology, and concentration. Conclusion: Wi-Fi exposure induces oxidative stress in the testis and affects important sperm parameters in rat pups. EBN supplementation quenched the oxidative stress activity due to Wi-Fi exposure and improved sperm quality.
Y. Fan, Ph.d., M. Hui, F. Li, Y. Chen, J. Liu, C. Huang,
Volume 22, Issue 2 (4-2024)
Abstract
Background: The research aims to construct a nomograph model for predicting distant metastasis of nasopharyngeal carcinoma after radiotherapy, and to evaluate the differentiation and consistency of the model. Materials and Methods: 292 nasopharyngeal carcinoma patients are selected and broken into a modeling group (204 cases) and a validation group (88 cases). The modeling group patients are further divided into a distant metastasis group (n=45) and a non-distant metastasis group (n=159). Logistic regression analysis is used to analyze the risk factors for distant metastasis of nasopharyngeal carcinoma after radiotherapy. Radiation therapy is performed on each group of patients and their lactate dehydrogenase, serum albumin, carcinoembryonic antigen are compared. Results: The proportion of age ≥ 60 years old, lymph node cystic invasion, laryngeal lymph node metastasis, T3-T4 staging, and N2-N3 staging in the distant metastasis group were higher than those in the non-distant metastasis group (P<0.05). Multiple logistic regression analysis denoted that age ≥ 60 years old, lymph node cystic invasion, laryngeal lymph node metastasis, T3-T4 stage, N2-N3 stage were risk factors for distant metastasis of nasopharyngeal carcinoma after radiotherapy (P<0.05). The Hosmer Limeshow goodness of fit test showed that the modeling group 2=5.489, P=0.601; Validation group 2=5.231, P=0.733. The areas under the receiver operating characteristic curves of the modeling group and the validation group were 0.828 and 0.822, respectively. Conclusion: The model constructed in this study for forecasting the risk of distant metastasis of nasopharyngeal carcinoma after radiotherapy has high prediction accuracy, good consistency, differentiation, and clinical applicability.
C. Xiaobo, D. Hui, Y. Juan,
Volume 22, Issue 3 (7-2024)
Abstract
Background: The link between the miR-499(rs3746444) gene polymorphism and genetic predisposition to hepatocellular carcinoma (HCC) was thoroughly assessed in this study. Materials and Methods: This study used Rev-Man 5.41 statistical software to conduct a meta-analysis of case-control studies that investigated the relationship between genetic susceptibility to HCC and the miR-499 gene or the rs3746444 locus polymorphism. The articles were searched in PMC, PubMed, and other databases. Results: In this analysis, 15 publications were used, with 4901 normal individuals serving as the control group and 3366 HCC patients as members of the experimental group. The findings showed that the risk of getting HCC was higher in those with the AA (95%CI (0.64, 0.94), I2 = 71%, P = 0.009) or AG (95%CI (1.01, 1.40), I2 = 58%, P = 0.04) genotypes. The risk of HCC was minimal when the genotype was GG (95%CI (0.79, 1.50), I2=56%, P = 0.60). A statistical difference was found between the G allele (95%CI (1.13, 1.69), I2 = 60%, P=0.002), while no significant difference was found between the two groups with respect to the A allele (95%CI (0.56, 1.15), I2 = 79%, P = 0.23). Conclusions: There was a strong link between the polymorphism of miR-499 gene and the genetic predisposition to hepatocellular cancer. Therefore, the polymorphism of the miR-499 gene can be utilized as a predictor of liver cancer occurrence, which is highly relevant for the early detection and management of liver cancer.
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