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Showing 2 results for Morsi
A.p. S.e. El Feky, O.s. Zahra, M.n. Salem, M.i. Morsi,
Volume 22, Issue 4 (10-2024)
Abstract
Background: Long non-coding RNAs (LncRNAs) play an important role in the biological and pathological processes of many cancers. LncRNA SChLAP1 and ATB have been shown to be overexpressed in a variety of cancers and may be involved in tumor cell invasion and metastasis. The goal of this study was to investigate the significance of lncRNA ATB and SChLAP1 expression in liquid biopsy of metastatic prostate cancer (PCa) relative to routine investigations. Materials and Methods: urine samples from 65 PCa patients we collected to assess ATB and SChlap1 by realtime PCR, serum samples were collected to assess PSA. Bone scan and clinicopathological data including Gleason sum, clinical stage, tumor size and lymph node involvement were collected. Results: A significant elevation in lncRNA SChLAP1 and ATB expression in bone scan-diagnosed metastatic PCa patients. Both markers were significantly associated with advanced clinical stage, Gleason sum and tumor size. SCHLAP1 expression has high specificity (100%) and moderate sensitivity (68%) at a cutoff point of 2.528. ATB expression has a high sensitivity (93.75%) and specificity (75.76%) at a cutoff value of 4.55. In univariate analysis, Gleason score (> 8), tumor size (> 2), lncRNA ATB express (>4.55), lncRNA SCHAP (>2.53), and PSA (> 35 pg/ml) were independently predictive of a positive bone scan. Only ATB was significant, regardless of the other adjusted factors. Conclusions: Expression levels of LncRNA SCHALP1 and ATB in PCa patients’ urine samples are promising, non-invasive markers that are associated with advanced clinicopathological parameters, including advanced clinical stage, high grade (Gleason sum) and larger tumor size.
D.s. Mansour, R.m. Morsi, Ph.d., A.m. Mousa,
Volume 22, Issue 4 (10-2024)
Abstract
Background: Radiation therapy is associated with a risk of long-term adverse effects. Ginger extract has several components that have many biological activities and vitamin c has also been recognized for protection against radiation-induced cell damage. The present study is designed to investigate the possible ameliorating effect of ginger extract and vitamin C on radiation-induced oxidative body damage. Ginger extract and vitamin C were daily given to rats during 14 days before starting irradiation. Materials and Method: Rats were exposed to gamma radiation (6 Gray). Results: the result revealed that the levels of lipid peroxidation measured in brain tissues such as malondialdehyde (MDA), acetylcholinesterase (AChE) were significantly increased, while reduced the activities of superoxide dismutase (SOD), catalase (CAT) and glutathione (GSH) content, dopamine (DA) and serotonin (ST) levels were significantly decreased in the brain homogenate of irradiated rats. Gamma-irradiation (6 Gy) resulted in a significant elevation in inflammatory markers of tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), interleukin-12 (IL-12) and C-reactive protein (CRP) compared to the control group. The rats that were administrated combined treatment with ginger extract and vitamin C showed significantly less severe damage and remarkable improvement in all of the last mentioned parameters when compared to irradiated rats. Conclusions: According to the results obtained it could be concluded that a combined treatment with ginger extract by its antioxidant constituents, and vitamin C might be a useful candidate against radiation-induced oxidative stress, enzyme activities in the brain and metabolic disorders without any toxicity.
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