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Showing 2 results for Nematollahi
S.m.j. Mortazavi, M. Foadi, H. Mozdarani, M. Haghani, M.a. Mosleh-Shirazi, P. Abolghasemi, S. Nematollahi, Dr. S. Sharifzadeh,
Volume 13, Issue 1 (1-2015)
Abstract
Background: Astronauts will be exposed to both chronic space radiation and acute high doses of energetic radiation of solar particle events in long-term deep space missions. The application of radioprotectors in space missions has basic limitations such as their very short time window as well as their acute toxicity and considerable side effects. The aim of the present study was to investigate the potential radiation mitigation effect of vitamin C that is known as an effective antioxidant and free radical scavenger. Materials and Methods: One hundred twenty male Wistar albino rats weighing 250-300 g were randomized into the following study groups: I, control II, Only exposure to gamma-radiation (LD50/30) treated with a single dose of vitamin C, III, 1h before irradiation, IV, V and VI, 1h, 12h and 24 h after irradiation. Measurement of cell viability and proliferation was also performed by using MTT cell proliferation assay. Results: The survival rate in animals received vitamin C 1h, 12h and 24h after irradiation were 55%, 60%, and 80%, respectively. The viability of cells in animals received vitamin C 1h, 12h and 24h after irradiation were 94.9%, 99.0%, and 100%, respectively. The viability of the cells in animals only exposed to gamma rays was 50.1%. Conclusion: These findings reveal that a single dose of vitamin C can potentially be used up to 24 hours after exposure to reduce the detrimental effects of high levels of ionizing radiation in cases such as the occurrence of currently unpredictable solar particle events.
S. Zarei, S. Tajbakhsh, M. Taheri, H. Mozdarani, A. Jafarzadeh, F. Nouri, S. Nematollahi, S. Dobaradaran, Ph.d., S.m.j. Mortazavi,
Volume 18, Issue 2 (4-2020)
Abstract
Background: The question of whether low levels of non-ionizing radiations such as the radiofrequency electromagnetic fields (RF-EMF) can induce the same positive immune responses remains unanswered. This study aimed to investigate the effects of non-ionizing RF-EMF on some parameters of the immune system in an animal model following infection with Salmonella Typhimurium and Klebsiella pneumoniae. Materials and Methods: Male BALB/c mice were exposed to RF-EMFs generated by a common GSM mobile phone for 3 days. Animals were infected with K. pneumonia or S. Typhimurium on the 4th day. On the7th day after injection, blood samples were collected by cardiac puncture. The specific antibodies against bacteria were determined by agglutination method and serum levels of the cytokines were measured using the ELISA method. Moreover, the leukocytes count was measured using a cell counter. Results: The levels of specific antibodies against bacteria were higher in non-irradiated mice compared to irradiated mice. There were no significant differences between the irradiated and non-irradiated mice regarding the total blood leukocyte count. The mean serum levels of IFN-γ and IL-17 after infection with K. pneumoniae were significantly higher in the irradiated mice (p<0.001). Conclusions: Low levels of RF-EMF can stimulate the immune responses in the mice pre-exposed to RF-EMF. This study provides further evidence supporting that exposure to certain levels of RF-EMF can stimulate the immune system. These adaptive responses may be applied to cope with the increased susceptibility of the astronauts to infections during a deep space mission.
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