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Showing 6 results for Tao
Y. Aoyama, T. Kataoka, S.h. Nakagawa, A. Sakoda, Y. Ishimori, F. Mitsunobu, Dr. K. Yamaoka,
Volume 9, Issue 4 (3-2012)
Abstract
Background: The aim of this study was to
analyze the effects of thoron and thermal treatment
for aging-related diseases in humans. Materials and
Methods: All subjects inhaled thoron with a high
concentration (about 4900 Bq/m3) for 2 weeks.
Blood pressures were measured and blood samples
were collected after each treatment 1, 2 and 3 weeks
after the first treatment. Results: The α-atrial
natriuretic peptide level of the rheumatoid arthritis
group was increased and the blood pressure was
significantly decreased. Superoxide dismutase
activity of rheumatoid arthritis group was significantly
increased by treatment. In addition, thoron and
thermal treatment significantly enhanced the concanavalin
A-induced mitogen response and increased
the level of CD4-positive cells it decreased the level
of CD8-positive cells. The results suggest that thoron
and thermal treatment activates antioxidative
function. Furthermore, these findings suggest that
thoron and thermal treatment prevents diabetic
ketoacidosis and contributes to the prevention of
aging-related diseases. Conclusion: Thoron and
thermal therapy may be part of the mechanism for
the alleviation of diabetes mellitus and rheumatoid
arthritis. Iran. J. Radiat. Res., 2012 9(4): 221-229
Z.c. Tao, J. Qiu, Y.y. Zhang, Dr. L. Qian, Dr. J. Gao, Y. Zhou, L. Yang, J. He, J. Yang, R. Wang, Y. Huang, L. Zhou, B. Sun, Y.y. Cui,
Volume 19, Issue 1 (1-2021)
Abstract
Previous studies show inconsistent effect estimates for the efficacy of Endostar in patients with advanced non-small cell lung cancer (NSCLC) undergoing chemoradiotherapy. Therefore, this meta-analysis aimed to determine the effectiveness and safety on the basis of data obtained from available randomized controlled trials (RTCs). We find relevant articles reporting the use of Endostar combined with chemoradiotherapy regimens in the treatment of advanced NSCLC. The retrieval period was from June 2008 to June 2018. A total of 11 RTCs that recruited a total of 735 patients were included. Overall, the results indicated that patients who received Endostar plus chemoradiotherapy showed a significantly increased incidence of objective response rate (ORR) (relative risk [RR] = 1.48; 95% confidence interval [CI] = 1.31–1.67; P < 0.00001) and disease control rate (DCR) (RR = 1.17; 95% CI = 1.09–1.25; P < 0.00001) compared with those who received chemoradiotherapy alone. However, no significant difference was noted between groups for 1-year survival rate (RR = 1.06; 95% CI = 0.91–1.23; P = 0.48). Furthermore, combined Endostar with chemoradiotherapy did not yield a high incidence of stable and elevated Karnofsky performance score (RR = 1.06; 95% CI = 0.91–1.23; P = 0.48). Moreover, no significant difference was noted in the incidence of total toxicity between the two groups. The findings of our study indicated that treatment with Endostar plus chemoradiotherapy yielded a high incidence of ORR or DCR, but did not trigger excess adverse events in patients with NSCLC.
W. Liu, Dr. M. Peng, F. Jiang, S.y. Wang, J.j. Liu, K. Tao, J. He,
Volume 20, Issue 2 (4-2022)
Abstract
Background: The Japanese clinical guidelines and the 2015 American Thyroid Association Management Guidelines recommend that indolent papillary thyroid microcarcinoma (PTMC) be monitored actively and that patients with aggressive PTMC immediately undergo surgery. This study aimed to establish a stage model and provide a reference for the preoperative identification of aggressive PTMC and indolent PTMC, which might guide the treatment of PTMC. Materials and Methods: Risk factors for the aggressive PTMC were identified through multivariate logistic regression analysis. According to the regression coefficient, each risk factor was assigned a risk score; thereafter, a risk score (RS) model and a stage model were established. Results: The tumor’s largest diameter > 6 mm, BRAFV600E (v-Raf murine sarcoma viral oncogene homolog B1, V600E) mutation, ultrasound-suspected lymph node metastasis, ultrasound-suspected extrathyroidal extension, and microcalcification were identified as risk factors for aggressive PTMC. The stage model was divided into three stages: stage I (RS=0.0; predictive probability for PTMC aggressiveness <10%), stage II (RS=1.0–2.3; predictive probability for PTMC aggressiveness, 10–50%), stage III (RS=3.2–7.6; predictive probability for PTMC aggressiveness, >50%). Based on the abovementioned results, stages I and II were considered to be probably indolent PTMC, and stage III was considered as probably aggressive PTMC. Conclusion: We suggest that patients with stages I and II PTMC be recommended for active surveillance, while those with stage III PTMC be recommended for immediate surgery.
L-R Zhou, L. Wang, Z-C Tao, M. Cheng, J. Gao, Dr. L-T Qian,
Volume 21, Issue 2 (4-2023)
Abstract
Background: While there have been marked improvements in radiotherapeutic techniques in recent years, the emergence of radioresistance remains a pressing challenge to the clinical treatment of esophageal squamous cell carcinoma (ESCC). Altered DNA methylation is believed to play a role in the etiology of such resistance. This study was designed to explore patterns of altered genome-wide gene expression and DNA methylation patterns in radioresistant ESCC cells (TE1-res) in an effort to provide a foundation for the future study of the molecular drivers that underlie this form of therapeutic resistance. Materials and Methods: A microarray-based approach was used to conduct genome-wide DNA methylation and gene expression analyses using matched radioresistant and radioresistant ESCC cells. The mechanistic basis for ESCC cell radioresistance was then further examined through functional enrichment and protein-protein interaction analyses. Results: Relative to parental TE1 cells, TE1-res cells exhibited marked changes in their DNA methylation profiles, with the disproportional distribution of differentially methylated CpG sites (dmCpGs) in CpG islands and shore regions. Ontological analyses revealed that genes that were differentially expressed and methylated were enriched in the Ras protein signal transduction, regulation of DNA damage response, and angiogenesis pathways. Protein-protein interaction analyses further suggested that ACTL8, M-RAS, TRIB2, GATA5, ERBB4, FN1, DIRAS1, BTK, ROR1, and NPR3 may serve as hub proteins within TE1-res cells. Conclusions: These analyses revealed a significant association between DNA methylation and TE1-res cell radioresistance, highlighting several candidate genes and pathways that may be amenable to clinical targeting in an effort to increase the radiosensitivity of these ESCC cells.
L. Chen, S. Dong, Ph.d., Y. Chen, L. Tian, C. He, S. Tao,
Volume 22, Issue 1 (1-2024)
Abstract
Background: A retrospective cohort study was conducted to analyze the diagnostic value and image features of chest computed tomography (CT) scan in children with lobar pneumonia (LP) before and after treatment. Materials and Methods: 172 children with lobar pneumonia treated from January 2016 to December 2021 were selected. The patients who underwent plain X-ray scan were divided into control group (n = 72) and the patients who underwent chest CT scan as study group (n = 100). The diagnostic value and image characteristics before and after treatment were compared between the two groups. Results: After treatment, the lesion area of the patient was absorbed in varying degrees, and the CT plain scan indicated that the solid shadow density decreased until it was completely absorbed. The sensitivity, specificity, accuracy, positive predictive value and negative predictive value of chest X-ray were 66.67%, 58.33%, 63.89%, 76.19% and 46.67% respectively; and chest CT scan were 82.98%, 67.92%, 75.00%, 69.64% and 81.82%. The sensitivity, specificity, accuracy, and negative predictive value of chest CT plain scan were higher, and the positive predictive value was lower compared to those of chest X-ray plain film. The results of ROC curve study indicated that the AUC of chest CT plain scan was 0.755 (95%CI=0.657-0.852), and the AUC of chest X-ray film was 0.625 (95%CI= 0.489-0.744). Conclusion: Chest CT has high sensitivity and specificity in the diagnosis of LP in children, which can clearly demonstrate the imaging features of LP before and after treatment.
L. Zhu, M.d., L. Chen, C. Du, N. Tao, J. Pan,
Volume 23, Issue 2 (5-2025)
Abstract
Background: To investigate the effects of laparoscopic ultrasound (LUS)-guided microwave ablation (MWA) combined with surgical resection on liver function and immune function of primary liver cancer (PLC) patients. Materials and Methods: Clinical data of 100 patients with PLC after surgery in our hospital from January 2021 to December 2023 were retrospectively analyzed, and divided into laparoscopic hepatectomy (LH group) and laparoscopic ultrasound-guided microwave ablation combined with laparoscopic hepatectomy (LMWA+LH group). Clinical indicators, clinical efficacy, liver function, tumor markers, immune function, incidence of complications, postoperative overall survival rate along with tumor free survival rate between groups were compared. Results: Compared with the LH group, the intraoperative blood loss and postoperative hospital stay was decreased in the LMWA+LH group (P<0.05). Total effective rate of the LMWA+LH group was 90.00%, higher than the 70.00% in LH group (P<0.05). After therapy, reduction in aspartate alanine aminotransferase (ALT), aminotransferase (AST), total bilirubin (TBIL), and the elevation in albumin (ALB) in the LMWA+LH group were more obvious (P<0.05). The LMWA+LH group showed more obvious elevation in CD4+ and CD4+/CD8+ levels and reduction in CD8+ level relative to the LH group (P<0.05). The complication incidence showed no statistical difference between groups (P>0.05). Postoperative survival and tumor free survival rates in the LMWA+LH group were higher than LH group (P<0.05). Conclusion: Laparoscopic ultrasound-guided microwave ablation combined with surgical resection promotes the postoperative recovery, improves liver function and immune function and improves patient survival rate, which might provide guidance for clinical practice.
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