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Showing 3 results for Zhuang
Y. Zhuang, W. Huang, Y. Shi, G. Bo, D. Lu, J. Zhang, D. Kong, Y. Shi, Dr. B. Wang,
Volume 16, Issue 2 (4-2018)
Abstract
Background: Prospectively electrocardiography (ECG)-triggered high-pitch spiral coronary computed tomography angiography (CCTA) is a unique scan mode for dual-source CT (DSCT). Our reports aim to compare image quality and radiation dose of CCTA using high-pitch spiral or sequential acquisition mode in patients with low and stable heart rates. Materials and Methods: Patients with low and stable heart rates (HR) (HR ≤ 70 beats per minute [bpm]; heart rate variability [HRV] < 10 bpm) were randomly assigned to high-pitch spiral mode (group A; n = 80) or sequential acquisition mode (group B; n = 80). Image quality scores, image noise, effective radiation dose and influencing factors on image quality were assessed. Results: Mean image quality scores were 1.51 ± 0.32 and 1.70 ± 0.38 for groups A and B (P < 0.05), respectively. Image noises of the two groups were 19.05±4.70 Hu and 27.21±8.88 Hu (P < 0.05). Contrast media cost in group A was lower than group B (P < 0.05). No statistical difference was found in the rate of diagnostic patients between the two groups (P = 0.416). The estimated radiation dose of group A was 26.0% reduced compared with group B (0.74 ± 0.34 mSv vs. 1.00 ± 0.48 mSv, P < 0.05). Conclusion: In patients with regular and low heart rates, the prospectively high-pitch spiral acquisition mode can reduce radiation dose and contrast media cost while maintaining image quality compared with the prospectively sequential mode.
Z. Dai, L. Zhu, A. Wang, X. Guo, Y. Liu, Y. Zhuang, P. Yang, Ph.d., N. Li, H. Zhang, Z. Xiang,
Volume 21, Issue 1 (1-2023)
Abstract
Background: The aim of this study was to make a comparison of plan quality between MLC-based EDGE and the cone-based CyberKnife systems in SBRT of localized prostate cancer. Materials and Methods: Ten patients with target volumes from 34.65 to 82.16 cc were included. Treatment plans were created for both systems using the same constraints. Dosimetric indices including target coverage, conformity index (CI), homogeneity index (HI), gradient index (GI) were applied for target, while the sparing of critical organs was evaluated with special dose-volume metrics and integral dose. Meanwhile, the delivery time and monitor units (MUs) were also estimated. The radiobiological indices such as equivalent uniform dose (EUD), tumor control probability (TCP) and normal tissue complication probability (NTCP) were also analyzed. Results: Both plans produced similar target coverage, HI and GI. For EDGE, more conformal dose distribution as well as reduced exposure of critical organs were obtained together with reduction of 91% delivery time and 72% MUs. EDGE plans also got lower EUD for bladder, rectum, urethra and penile bulk, which associated with reduction of NTCPs. However, higher values of EUD and TCP for tumor were obtained with CK plans. Conclusion: It indicated that both systems were capable of producing almost equivalent plan quality and can meet clinical requirements. CyberKnife has higher target dose while EDGE system has more advantages in normal tissue sparing and delivery efficiency.
Z. Song, M. Zhuang, Z. Jin, Y. Gao, B. Bian,
Volume 22, Issue 2 (4-2024)
Abstract
Background: Clinical stage and the ability to achieve comprehensive treatment were the prognostic features of thymoma. In the present study, we aimed to analyze the efficacy of different types of therapy in patients with Masaoka-Koga stage III thymoma. Materials and Methods: From 2001 to 2018, patients newly diagnosed with thymoma was retrospectively analyzed. The c2test was used to evaluate patient characteristics, the Kaplan-Meier method was used to calculate overall survival (OS), log-rank method was applied to examine the difference between groups, and Cox regression was used to analysis the potential prognostic factors of OS. Results: The median follow-up time was 50 months (range: 3-221 months), and median OS was 51 (range: 3-221) months. The radical surgery group had a significantly better OS than the palliative surgery group. The 5- year, 10-year OS were 88.2%, 74.4% in the radical surgery group, whereas the 5- year, 10-year OS were 51.8% and 32.4% in the palliative group. The 5-year OS in surgery followed by adjuvant radiotherapy group was higher than that of surgery alone group (82.8% vs 55.8%, P=0.033); similarly, the 10-year OS of the two groups were 64.2% and, 50.2%, respectively (P＜0.05). Multivariate analysis revealed that age < 50 years (HR [hazard ratio]: 0.264), radical resection (HR:0.134, P=0.000), and surgery combined with radiotherapy (HR:2.778, P=0.009) were independently associated with better OS. Conclusion: In Masaoka-Koga stage III thymoma, patients treated with radical surgery was capable of achieving better OS than patients treated with palliative surgery. Moreover, radical surgery was an independent factor of prognosis.
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