|
|
|
 |
Search published articles |
 |
|
Showing 3 results for Zinc Oxide
N. Banaee, Dr. H.a. Nedaie, A.r. Shirazi, A.r. Zirak, S. Sadjadi,
Volume 14, Issue 2 (4-2016)
Abstract
Background: New treatment modalities are developed with the aim of escalating tumor absorbed dose and simultaneously sparing the normal structures. The use of nanotechnology in cancer treatment offers some possibilities including destroying cancer tumors with minimal damage to healthy tissues. Zinc Oxide nanoparticles (ZnO NPs) are wide band gap semiconductors and seem to have a good effect on increasing the absorbed dose of target volume especially when doped with a high Z element. The aim of this study was to evaluate the effect of ZnO NPs doped with Gadolinium (Gd) on dose enhancement factor by 6MV photon beam irradiation. Materials and Methods: Various concentrations of ZnO NPs doped with 5% Gd were incorporated into PRESAGE composition, the 3D chemical dosimeter. Then by using a UV-Vis spectrophotometer optical density changes and also dose enhancement factor (DEF) were determined. Results: The results of this study showed that by incorporating 500, 1000, 3000 and 4000 µg/ml ZnO NPs doped with Gd into PRESAGE structure the dose enhancement factor of about 1.57, 1.69, 1.78 and 1.82 in a 15 ×15 cm2 field size could be found, respectively. Conclusion: The results of this study showed that ZnO NPs doped with Gd could be considered as new compound for increasing the absorbed dose.
A.m.a. Al-Asady, Dr. N.n.a. Razak, M.h.m. Zin, S. Mahmud,
Volume 20, Issue 2 (4-2022)
Abstract
Background: : One of the most important qualities of a radiation dosimeter is tissue-equivalent, which represents radiation absorption and scattering that is similar to that of human tissue. The goal of this study is to determine the radiological and structural properties of several MAGAT gel dosimeter formulations prior to irradiation. This will provide a basis on how radiation properties altered prior to irradiation, which will later affect radiation absorption behaviour. Materials and Methods: Radiological properties of different MAGAT gel formulations (MAGAT, MAGAT doped methylene blue, MAGAT doped zinc oxide nanoparticles, MAGAT dope methylene blue and zinc oxide nanoparticles) were measured from density, linear attenuation coefficients, mass attenuation coefficients and CT values. The results were compared to soft tissue and water as references. The gel’s morphological structures were investigated using electron microscopy for better understanding of gel’s absorption mechanism. Results: The mass density of all MAGAT gel formulations differed by up to 2.5% from that of water and are very close to that of muscle tissue. This is due to the high gelatin and monomer concentration used in MAGAT gel formulation. The CT-values, furthermore, are within the soft tissue range. The MAGAT doped with methylene blue and ZnO NPs demonstrated the greatest increase in linear attenuation value, as well as having a nano spider-web morphological structure with a large surface area, which may have increased gel sensitivity and attenuation coefficients of MAGAT gel. Conclusion: Different MAGAT gel formulations were found to exhibit similar radiological properties to soft tissues and water.
Ph.d., R.m. Shaheen, Ph.d., N.n.a. Bt Nik Ab Razak, M.m. Radhi, N. Binti Suardi, M. Mohammed,
Volume 22, Issue 1 (1-2024)
Abstract
Background: Gadolinium (Gd) is a widely used MRI contrast agent that improves visibility and aids in accurate diagnosis. However, conflicting reports exist regarding its genotoxic effects. This study investigates the bio-effects of Gd and alternative contrast media, magnesium chloride (MgCl2), and zinc oxide nanoparticles (ZnO NPs) on DNA single-strand breaks. Materials and Methods: In this in-vitro comparative experiment, 12 adult New Zealand rabbits (males aged between 4.5 to 5.5 months, weighing 2.5 to 3.0 kg) were utilized. The rabbits received intravenous injections of different contrast agents, namely Gd (n=3), MgCl2 (n=3), ZnO NPs (n=3), and a control group (n=3). Following this, all the rabbits were subjected to MRI at 1.5 Tesla (T) with an RF of 64 MHz for 20 minutes. The alkaline comet assay assessed the presence of single-strand breaks (SSB). Results: The results of the study revealed a statistically significant increase in DNA SSB in both the Gd (p<0.010) and ZnO NPs (p=0.006) treated groups compared to the normal control group. However, the alternative MgCl2 treatment did not elicit a statistically significant effect on the DNA single-strand compared to the control group (p=0.277). Conclusion: The contrast medium Gd and alternative ZnO NPs were demonstrated to cause significant DNA single-strand breaks, with the Gd causing more damage than ZnO NPs. However, the alternative contrast MgCl2 was safer with no effect on DNA single-strand. This suggests that MgCl2 is more suitable as an alternative contrast media in MRI scanning.
|
|
