|
|
|
 |
Search published articles |
 |
|
Showing 7 results for Antioxidants
M. Rezvani,
Volume 1, Issue 2 (9-2003)
Abstract
E.m. Kamal El-Dein Kamal El-Dein, Ph.d., L.m. Anees,
Volume 18, Issue 4 (10-2020)
Abstract
Background: This work aimed at studying the protective effect of melatonin (MLT) against cypermethrin or γ-radiation induced testicular damage. Material and Methods: Thirty six Male rats were randomly divided into 6 groups. Control group, group treated with MLT (10 mg/Kg b. wt.), group administered cypermethrin (25 mg/ kg. b. wt.), group 4 was exposed to fractionated whole body γ-radiation (the sum=8 Gy), group 5 was co-administered with MLT (10 mg/Kg .b. wt.) and cypermethrin (25 mg/kg b. wt.) and finally group 6 rats were supplemented with MLT (10 mg/Kg .b. wt.) and subsequently administered fractionated γ-radiation(the sum=8 Gy). After treatment for 29 successive days, all animals groups were investigated for hormonal assay, sperm quality, oxidative indices and histological examination of testicular tissues. Results: Rat’s treatment with g-radiation or Cypermethrin showed a significant decrease in body weight, testis, epididymis, ventral prostate and seminal-vesicles weights. Also, a significant increase was observed in the levels of TBARS and H2O2, while a significant reduction occurred in the activity of SOD, CAT and GSH content in testis tissues, in addition to a significant decrease in testosterone hormone. On the other hand, a significant increase occurred in FSH and prolactin hormones .moreover, a significant decrease in sperm count and motility occured beside a significant increase in abnormal forms. Pretreatment of rats with MLT improved the disturbances induced in the tested parameters of rats either received cypermethrin or γ-irradiation. Conclusion: According to the present findings, the ameliorative role of MLT is obvious against cypermethrin or γ-irradiation induced testicular damage probably, due to its antioxidative properties.
K.c. Ogbanya, E.k. Mgbe, E.o. Modebe, I.g. Abah, T.o. Nnaji,
Volume 22, Issue 3 (7-2024)
Abstract
Background: The study investigates the effects of four different doses of computed tomography (CT) x-ray radiation on the oxidation markers, endogenous antioxidant enzymes, and lipid profiles of male Wistar albino rats. Materials and methods: Thirty healthy male Wistar albino rats weighing 180-200g were assigned into five groups of 6 rats each. Rats in groups A, B, C, and D underwent non-contrast helical total body irradiation and received varying doses of CT radiation, while group E received sham irradiation and served as a control. Glutathione peroxidase (GPx), superoxide dismutase (SOD), catalase (CAT) activities, serum levels of malondialdehyde (MDA), oxidized glutathione (GSSG), nitric oxide (NO), total cholesterol (TC), low-density lipoprotein (LDL), high-density lipoprotein (HDL), and triglycerides were investigated using standard methods. Results: At 72 hours’ post-irradiation, the mean serum activities of GPx, SOD, and CAT in the irradiated groups decreased significantly, while the serum levels of MDA, GSSG, TC, and LDL increased significantly compared to the control. Conclusion: The four different doses of CT radiation in the current study caused a significant decline in the endogenous antioxidant enzymes (GPx, SOD, and CAT) and, in contrast, induced a significant serum elevation of MDA and GSSG in the irradiated rats. The LDC and TC mean serum levels were also significantly elevated in the irradiated groups.
A.a. Abe, O.a. Ayannuga, F.a. Balogun,
Volume 22, Issue 3 (7-2024)
Abstract
Background: Chronic oxidative stress is hypothesized to precede radiation-induced brain injury in irradiated brains. This study investigated the antioxidant activity and radioprotective effects of Vitis vinifera L. seed in Wistar rats following fractionated whole-brain irradiation. Materials and Methods: Seventy-two young adult male Wistar rats were randomly selected and divided into three equal groups. Group A was the control group, while Groups B and C received a total dose of 40 Gy of 60Co gamma radiation to the head. The radiation dose was fractionated at 5 Gy per exposure. In addition, group C rats were orally administered 100 mg/kg/day of Vitis vinifera L. seeds starting from one week before exposure and lasting until the time of sacrifice. At weeks 1, 2, 3, and 4 post-irradiations, the average brain weights, total brain protein concentration, and superoxide dismutase activity of the rat brains were determined. Results: The study recorded significant reductions in the average brain weights, total brain protein concentration, and brain superoxide dismutase activity in group B rats when compared to groups A and C (P < 0.05). However, the study found that group C rats had a higher total brain protein concentration (P > 0.05), correlative average brain weight (P > 0.05), and a significant increase in brain superoxide dismutase activity (P < 0.05) when compared with group A rats. Conclusions: Vitis vinifera L. seed has antioxidant and radioprotective effects on irradiated rat brains.
D.s. Mansour, R.m. Morsi, Ph.d., A.m. Mousa,
Volume 22, Issue 4 (10-2024)
Abstract
Background: Radiation therapy is associated with a risk of long-term adverse effects. Ginger extract has several components that have many biological activities and vitamin c has also been recognized for protection against radiation-induced cell damage. The present study is designed to investigate the possible ameliorating effect of ginger extract and vitamin C on radiation-induced oxidative body damage. Ginger extract and vitamin C were daily given to rats during 14 days before starting irradiation. Materials and Method: Rats were exposed to gamma radiation (6 Gray). Results: the result revealed that the levels of lipid peroxidation measured in brain tissues such as malondialdehyde (MDA), acetylcholinesterase (AChE) were significantly increased, while reduced the activities of superoxide dismutase (SOD), catalase (CAT) and glutathione (GSH) content, dopamine (DA) and serotonin (ST) levels were significantly decreased in the brain homogenate of irradiated rats. Gamma-irradiation (6 Gy) resulted in a significant elevation in inflammatory markers of tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), interleukin-12 (IL-12) and C-reactive protein (CRP) compared to the control group. The rats that were administrated combined treatment with ginger extract and vitamin C showed significantly less severe damage and remarkable improvement in all of the last mentioned parameters when compared to irradiated rats. Conclusions: According to the results obtained it could be concluded that a combined treatment with ginger extract by its antioxidant constituents, and vitamin C might be a useful candidate against radiation-induced oxidative stress, enzyme activities in the brain and metabolic disorders without any toxicity.
Ph.d., H. Mozdarani, S. Mozdarani, F. Pakniyat, S. Mozdarani, H. Nosrati,
Volume 23, Issue 1 (1-2025)
Abstract
Background: Due to high radiation- sensitivity of breast cancer (BC) patients, use of radioprotectors to ameliorate the deleterious effects of radiation could be a priority. This study aimed to evaluate the reducing effects of saffron and melatonin on ionizing radiation-induced damages in lymphocytes of luminal A & B BC patients using cytome assay. Materials and Methods: Whole blood samples were collected from BC patients as well as healthy individuals. Cells were treated with either melatonin or saffron two hours prior to irradiation of G0 lymphocytes using a 6 MV linear accelerator, at a dose of 3Gy. Thirty-six hours after PHA stimulation, Cytochalasin-B was added to the cultures. Cell harvesting and staining was performed using standard method. 1000 binucleate cells were scored per sample for the frequency of micronuclei (MN) or apoptosis under a 1000x light microscope. Results: The frequency of background MN was significantly lower in normal individuals compared to BC patients. Pretreatments of "saffron and melatonin" alone made no significant changes in the frequency of MN in all groups. However, after 3Gy-irradiation the frequency of MN elevated dramatically (p<0.01). Pretreatment of lymphocytes with melatonin and saffron led to a decrease in the frequency of MN in all treatment groups (p<0.05). In terms of apoptosis induction, only melatonin was found to exert reducing effect on radiation induced apoptosis. No radioprotection was observed for saffron in lymphocytes of BC patients. Conclusion: Obtained results elucidated more pronounced role of melatonin in decreasing MN and apoptosis frequencies post irradiation in lymphocytes of BC patients.
H.a. Akbari, Ph.d., A.a. Gaeini, M.r. Kordi, A.a. Ravasi A.a. Ravasi,
Volume 23, Issue 1 (1-2025)
Abstract
Background: Oxidative stress-induced tissue damage is a recognized concern linked to electromagnetic radiation (EMR) waves. Materials and Methods: In the present study, we explored the effect of moderate aerobic exercise (AE) on oxidative stress (OS) and cardiomyocyte damage resulting from cell phone EMR in rats. A total of 32 male Wistar rats were randomly allocated into the following groups: control (C), EMR, AE, and EMR+AE. Both EMR+AE and EMR groups were subjected to three hours of daily cell phone EMR (0.9-1.8 GHz) exposure for six weeks, while the AE and EMR+AE groups completed a treadmill AE five days per week. The heart was collected 48 hours after the last AE session to assess OS, histopathological damage, and left ventricular structure. Results: Tissue sections revealed that the EMR group had more significant heart tissue damage (increased apoptotic cells and collagen deposition) than the C group, and adding AE mitigated the damage (P<0.05). In the EMR group, in comparison to the EMR+AE, C, and AE groups, the activity of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPX) significantly decreased, and the concentration of malondialdehyde (MDA) elevated notably (P < 0.05). Exercise training in both the AE and EMR+AE groups resulted in a notable rise in SOD, CAT, and GPX activity, alongside a notable reduction in MDA concentration in comparison to the EMR group (P < 0.05). Conclusions: AE is advantageous in mitigating the adverse impacts of EMR emitted from mobile phones on the heart.
|
|
