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Showing 3 results for Ethanol
Ph.d., S. Kim, Ph.d., E. Han,
Volume 18, Issue 3 (7-2020)
Abstract
Background: we aimed to find the optimal level of ethanol that can be added such that the radiochemical purity of [18F]FDG is increased and the MFDS and USP stipulated guidelines are met. Materials and Methods: Changes in the radiochemical purity of [18F]FDG were analyzed according to changes in the concentrations of ethanol added. The study used 1 L of 99.9% pure ethanol. The ethanol concentrations used were 0.0% (0 µL) for the control group and 0.1% (1 µL), 0.2% (2 µL), and 0.3% (3 µL) for the experimental groups. Since the radiochemical purity of [18F]FDG may differ according to the radioactive concentrations used, four different radioactive concentrations were prepared: 1580 mCi/16 mL, 3320 mCi/16 mL, 4840 mCi/16 mL, and 6470 mCi/16 mL. Results: The radiochemical purity of [18F]FDG increased significantly when ethanol was added to it at different radioactive concentrations in comparison to when ethanol was not added. When ethanol concentrations of 0.1%, 0.2%, and 0.3% were added, the radiochemical purity increased at all radioactive concentrations (100 mCi/mL, 200 mCi/mL, 300 mCi/mL, and 400 mCi/mL) while meeting the KP and USP standards even after 10 hours following the EOS. Conclusion: It was determined in our study that adding ethanol at the concentration of 0.1% to [18F]FDG is most suitable as it generates the least residual ethanol while maintaining the radiochemical purity of [18F]FDG at stable levels that meet the KP and USP standards.
L. Li, J. Luo, Ph.d., H. Lu,
Volume 21, Issue 4 (10-2023)
Abstract
Background: To investigate the difference in the effect of ultrasound-guided puncture injection of polidocanol (PO) and ethanol (ET) in the treatment of renal and hepatic cysts (RHC), and to analyze the factors related to patients’ prognosis of disease recurrence. Materials and Methods: A total of 105 patients with RHC admitted to our hospital from August 2020 to August 2021. Among them, 59 patients received ultrasound-guided puncture injection of ET (control group); the rest 46 received ultrasound-guided puncture injection of PO (observation grou). The success rate of one-time puncture and adverse reactions of the two groups were counted, and the levels of C-reactive protein (CRP), Cortisol (Cor), liver and kidney function. Patients were then followed up for a one-year prognosis, and the prognosis of RHC recurrence was recorded. Logistic regression analysis was performed to analyze the factors associated with the recurrence of cysts. Results: Postoperative CRP and Cor were observed to be lower than those in the control group, and hepatic and renal function was better than that in the control group (P<0.05). In addition, the incidence of adverse reactions was lower in the observation group than in group B (P<0.05). Cyst diameter, incomplete cyst aspiration, and post-sclerotic segregation were high-risk independent factors affecting prognostic cyst recurrence (P<0.05). Conclusion: Ultrasound-guided injection of PO puncture sclerosis for RHC has excellent results. At the same time, patients need to be concerned about the diameter of the cyst, incomplete aspiration of the cystic fluid, and whether the cyst is separated after sclerosis.
A.a. Mansour, Ph.d., A.m. Abdul Azeem, A.n. El Shahat, M.h.m. Abd El Megid,
Volume 22, Issue 1 (1-2024)
Abstract
Background: This study aimed to evaluate the effects of gamma rays and electron beams (5kGy) on the chemical content of dried fig leaves. In addition, the hepatoprotective effect of irradiated-dried fig leaves powder (GFLP) against ethanol (EtOH)-induced hepatotoxicity in rats was investigated. Materials and Methods: The 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity, sugar, total phenolic, total flavonoid content, phytate, and tannin contents of either raw or irradiated dried fig leaves were detected in this study. For the experimental study, 28 male rats were divided into four groups; Group C, control; Group 2: received an oral dose of ethanol (0.5 ml/100 gm b.wt. /day /5 weeks) and Groups 3-4: rats fed daily (60 min after EtOH injection) on either raw or irradiated fig leaves powder (4% of the weight of the diet). Results: It was observed from the results that gamma-irradiation (5 kGy) resulted in a higher increase in DPPH radical scavenging activity, sugar, total phenolic and total flavonoid content, and a higher reduction in phytate and tannin contents than e-beam irradiation. The results of the experimental study revealed that treatment of EtOH-rats with GFLP resulted in a significant reduction in the serum blood alcohol level, the activity of some liver enzymes, level of tumor necrotic factor-alpha, interleukin-6, malondialdehyde, and lipid profile contents associated with significant elevation in the level of high-density lipoprotein-cholesterol, hepatic total antioxidant capacity and glutathione content relative to EtOH-group. Conclusion: The enhanced antioxidant activities of Ficus carica leaves through irradiation could be applied as a natural antioxidant source in foodstuff.
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