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Showing 2 results for Focal Nodular Hyperplasia
X.h. Ge, M.d., J.f. Zhang,
Volume 18, Issue 4 (10-2020)
Abstract
Background: The objective was to explore the value of the CT value difference (△HU) and CT value ratio (CVR) between the hepatic arterial (AP), portal (PP), and delayed phases (DP) to differentiate the small Hepatocellular Carcinoma (SHCC, ≤ 3 cm) from the small Focal nodular hyperplasia (SFNH, ≤ 3 cm). Materials and Methods: All the lesions were confirmed by clinically and/or pathologically and all the patients underwent triple-phase enhanced CT scans. The lesions’ CT values (LCV) and the surrounding normal liver parenchyma (NCV) of the enhancement phases were measured separately, the △HU and CVR were calculated. Results: The median age and the male/female ratios of the SHCC and SFNH have statistically significant, and the size haven’t statistically significant. The △HU and CVR of the AP, PP, and DP of the SHCCs and SFNHs were statistically significant, respectively. The area under curve of △HU and CVR of AP, PP and DP were increased gradually. When the △HU and CVR of the AP, PP and DP were 105.800HU vs. 1.516, -12.600HU vs. 0.949, -19.750 HU vs. 0.951, obtained the maximum You-den indexes. The corresponding sensitivity and specificity were 80.6 % and 90.1 % vs. 88.90% and 72.1%, 100% and 81.1% vs. 100% and 81.1%, 94.4 % and 96.4% vs. 94.4 % and 96.4%, respectively. Conclusion: The SHCC was highly suggested when △HU and CVR are no greater than 105.800HU and 1.516, -12.600HU and 0.949, -19.750 HU and 0.951 of the AP, PP, and DP in the middle-aged and elderly male patients, especially in the DP.
X. Zhu, Q. Feng, X. Ge, B. Hu,
Volume 22, Issue 3 (7-2024)
Abstract
Background: Here, we aimed to quantitatively analyze the gray scale value (GSV) of conventional triple-enhancement MRI and explore its value in differentiating non-cirrhosis, alpha-fetoprotein-negative small Hepatocellular carcinoma (SHCC) together with Focal nodular hyperplasia (SFNH). Materials and Methods: In this study, 83 cases of SHCC-related lesions were observed in 83 individuals, and an additional 35 cases of SFNH-associated lesions were examined in a group of 32 patients. These lesions were all verified through pathological assessment. The lesions’ MRI GSV of the plain scan (GSV-p) and the enhanced MRI scan (GSV-c), and normal liver parenchyma’s GSV around the lesion (GSV-n) were all quantified. Subsequently, we computed the GSV-c to GSV-n ratio (GSR), and the GSV-c to GSV-p ratio (GSRL). We employed the Wilcoxon rank sum analysis and ROC curve analysis with the aim of evaluating significance in these ratios. Results: Age and gender distribution in SHCC and SFNH exhibited relevant differences, whereas the size did not. During the phases arterial (GSRAP), portal (GSRPP), and delayed (GSRDP), the GSR and the GSRL for SHCC and SFNH demonstrated a gradual decrease, and all these changes were statistically significant. The AUC for GSRDP in SHCC and SFNH was 0.83, which surpassed the performance of other metrics. Conclusions: The GSV values obtained from a standard triple-enhancement MRI were found to be valuable in distinguishing between SHCC and SFNH, with the GSRDP showing the best performance. The precise utilization of these metrics facilitated the differentiation of SHCC and SFNH, ultimately reducing the need for unnecessary interventional procedures and associated trauma.
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