|
|
|
 |
Search published articles |
 |
|
Showing 1 results for Genetic Susceptibility
C. Xiaobo, D. Hui, Y. Juan,
Volume 22, Issue 3 (7-2024)
Abstract
Background: The link between the miR-499(rs3746444) gene polymorphism and genetic predisposition to hepatocellular carcinoma (HCC) was thoroughly assessed in this study. Materials and Methods: This study used Rev-Man 5.41 statistical software to conduct a meta-analysis of case-control studies that investigated the relationship between genetic susceptibility to HCC and the miR-499 gene or the rs3746444 locus polymorphism. The articles were searched in PMC, PubMed, and other databases. Results: In this analysis, 15 publications were used, with 4901 normal individuals serving as the control group and 3366 HCC patients as members of the experimental group. The findings showed that the risk of getting HCC was higher in those with the AA (95%CI (0.64, 0.94), I2 = 71%, P = 0.009) or AG (95%CI (1.01, 1.40), I2 = 58%, P = 0.04) genotypes. The risk of HCC was minimal when the genotype was GG (95%CI (0.79, 1.50), I2=56%, P = 0.60). A statistical difference was found between the G allele (95%CI (1.13, 1.69), I2 = 60%, P=0.002), while no significant difference was found between the two groups with respect to the A allele (95%CI (0.56, 1.15), I2 = 79%, P = 0.23). Conclusions: There was a strong link between the polymorphism of miR-499 gene and the genetic predisposition to hepatocellular cancer. Therefore, the polymorphism of the miR-499 gene can be utilized as a predictor of liver cancer occurrence, which is highly relevant for the early detection and management of liver cancer.
|
|
