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Showing 1 results for Superoxide Dismutase

A.a. Abe, O.a. Ayannuga, F.a. Balogun,
Volume 22, Issue 3 (7-2024)
Abstract

Background: Chronic oxidative stress is hypothesized to precede radiation-induced brain injury in irradiated brains. This study investigated the antioxidant activity and radioprotective effects of Vitis vinifera L. seed in Wistar rats following fractionated whole-brain irradiation. Materials and Methods: Seventy-two young adult male Wistar rats were randomly selected and divided into three equal groups. Group A was the control group, while Groups B and C received a total dose of 40 Gy of 60Co gamma radiation to the head. The radiation dose was fractionated at 5 Gy per exposure. In addition, group C rats were orally administered 100 mg/kg/day of Vitis vinifera L. seeds starting from one week before exposure and lasting until the time of sacrifice. At weeks 1, 2, 3, and 4 post-irradiations, the average brain weights, total brain protein concentration, and superoxide dismutase activity of the rat brains were determined. Results: The study recorded significant reductions in the average brain weights, total brain protein concentration, and brain superoxide dismutase activity in group B rats when compared to groups A and C (P < 0.05). However, the study found that group C rats had a higher total brain protein concentration (P > 0.05), correlative average brain weight (P > 0.05), and a significant increase in brain superoxide dismutase activity (P < 0.05) when compared with group A rats. Conclusions: Vitis vinifera L. seed has antioxidant and radioprotective effects on irradiated rat brains.


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International Journal of Radiation Research
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