AU - Ozmen, O. AU - Ipek, V. AU - Tasan, S.A. AU - Ayozger, L.E.O. AU - Altintas, M. TI - Effects of repeated ultraviolet-C radiation on tissues: A Guinea pig model study PT - JOURNAL ARTICLE TA - Int-J-Radiat-Res JN - Int-J-Radiat-Res VO - 21 VI - 1 IP - 1 4099 - http://ijrr.com/article-1-4568-en.html 4100 - http://ijrr.com/article-1-4568-en.pdf SO - Int-J-Radiat-Res 1 ABĀ  - Background: Due to the disinfection and antibiotic resistance of microorganisms, there is a growing interest in ultraviolet-C (UV-C). UV-C has numerous advantages, and the applications of this method for fluids, surfaces, and air are rapidly expanding. However, nothing is known about how UV-C affects living bodies. This study's objective is to assess the results of 10 sessions of 10- to 20-minute UV-C exposure on healthy guinea pigs. Materials and Methods: After five days of UV-C treatment, blood and visceral organ samples were collected and analyzed. Results: Moreover, the hematological and biochemical analyses of the blood samples revealed no significant changes. According to histopathological examination, UV-C treatment did not cause any damage to internal organs. Except for the intestine, caspase-3 immunohistochemistry revealed no increase in apoptotic activity. In the UV-C-treated groups, only minor apoptotic activity was observed in intestinal goblet cells. Conclusion: This study found that repeated UV-C exposure for ten sessions lasting 10-20 minutes did not result in any pathological findings in the guinea pig model. This result suggested that UV-C could be used for barn and pen disinfection when animals are present as well as udder disinfection prior to milking. CP - IRAN IN - Burdur Mehmet Akif Ersoy University, Faculty of Veterinary Medicine, Department of Pathology, Burdur, Turkey LG - eng PB - Int-J-Radiat-Res PG - 45 PT - Original Research YR - 2023