%0 Journal Article %A Kiziltan, H.S. %A Eris, A.H. %A Meral, I. %A Seyithanoglu, H. %A Dundar, T. %A Eren, F. %A Unver, N. %A Aydin, T. %A Mayadagli, A. %A Bayir, A.G. %A Celikten, M. %T Peri-operative radiotherapy for the prevention of post-operative fibrosis on rats %J International Journal of Radiation Research %V 16 %N 4 %U http://ijrr.com/article-1-2401-en.html %R %D 2018 %K Laminectomy, peri-operative radiotherapy, fibrosis, rotarod tests., %X Background: Post-operative fibrosis related pains and functional anomalies can be serious problems for patients. Radiotherapy (RT) could inhibit fibrosis which may occurs post- operation especially following laminectomy. Therefore, this study was designed to investigate the effect of peri-operative RT on the prevention of post-operative fibrosis and scar formation on rats. Materials and Methods: Twenty three male Wistar albino rats, were divided into three experimental groups. Laminectomy was performed to L3 and L4 lomber vertebral regions of group L and L+R rats. The rats in L+R group in addition to this procedure also received peri-operative RT on the laminectomy area. A total dose of 700 cGy of RT was applied as a single fraction using electrons. Control rats received no treatment. A rotarod test was performed at 20, 30 and 40 rpm/min speed rates to determine the physical performances of the rats. Results: The results have indicated statistically significant (P<0.05) differences for the 30 rpm/min rotarod test between the L and L+R groups. Histopatologically, significant differences were observed in epidural fibrosis, fibroblast cell density and arachnoid adhesion between the L and L+R groups. Conclusion: It was concluded that peri-operative RT may provide a significant advantage for prevention post-laminectomic of scar tissue formation. %> http://ijrr.com/article-1-2401-en.pdf %P 481-485 %& 481 %! The prevention of fibrosis with radiotherapy %9 Short Report %L A-10-1-747 %+ Department of Radiation Oncology, Bezmialem Vakif University, Faculty of Medical, 34093 Fatih, Istanbul, Turkey %G eng %@ 2322-3243 %[ 2018