AU - Hu, X.S. AU - Wen, S.M. AU - Bie, J. AU - Xian, F. AU - He, W.W. AU - Li, D. TI - Surgery or radiotherapy, which is more effective for upper esophageal carcinoma? A retrospective cohort study based on 191 cases PT - JOURNAL ARTICLE TA - Int-J-Radiat-Res JN - Int-J-Radiat-Res VO - 17 VI - 4 IP - 4 4099 - http://ijrr.com/article-1-2675-en.html 4100 - http://ijrr.com/article-1-2675-en.pdf SO - Int-J-Radiat-Res 4 AB  - Background: To compare radical surgery with definitive radiotherapy for upper third esophageal squamous cell carcinoma. Materials and Methods: A total of 191 patients were included in the study. Patients’ clinicopathologic features, and survival time were recorded. Kaplan-Meier (K-M) analysis was adopted to analyze Overall survival (OS), Disease-free survival(DFS), Progression-free survival(PFS), and a Cox multivariate model was used to adjust potential confound factors. Results: The K-M survival analysis showed that treatments, location of lesion, and length of lesion were all associated with the OS (P<0.005). In the surgery group, K-M survival showed that T stage (T1 vs T2, P=0.012, T1 vs T3, P=0.002), location (upper vs upper merged middle, P<0.001), and length lesion (<5 cm vs >5 cm, P=0.015), affected the OS,T stage (T1 vs T2, P=0.018, T1 vs T3, P=0.020) and location of lesion (upper vs upper merged middle, P=0.007) was associated with DFS. The Cox model showed that none of these parameters independently influenced the OS and DFS. In the radiotherapy group, K-M survival showed that supraclavicular lymph node metastasis (P=0.007), concurrent chemo-radiotherapy (P=0.012), and sex (P=0.047) influenced the OS,adjuvant chemotherapy (P=0.013) and age (P=0.013) influenced PFS, The Cox model showed that supraclavicular lymph node metastasis (P=0.018) independently influenced OS and adjuvant chemotherapy (P=0.046) independently influenced PFS. Conclusion: Surgery has better therapeutic effect than radiotherapy. Patients with an upper merged middle lesion and advanced T stage for surgery, male, local advanced and without concurrent chemo-radiotherapy for radiotherapy have a poor prognosis. CP - IRAN IN - Department of of Oncology, The Second Xiangya Hospital of Central South University, 410011Changsha, Hunan, China&Department of Oncology, Nanchong Central Hospital, 637000Nanchong, Sichuan, China LG - eng PB - Int-J-Radiat-Res PG - 595 PT - Original Research YR - 2019