AU - Jahanbani, S.S.A. AU - Rezaeyan, A.H. AU - Ghaffari, H. AU - Babae, A.R. AU - Haddadi, G.H. AU - Moeni, M.M. AU - Jomehzadeh, A. AU - Moatamedi, S. AU - Eftekhar-Vaghefi, S.H. TI - Investigation of the radioprotective effect of arbutin on radiation-induced lung injury in rats: a histopathological study PT - JOURNAL ARTICLE TA - Int-J-Radiat-Res JN - Int-J-Radiat-Res VO - 18 VI - 3 IP - 3 4099 - http://ijrr.com/article-1-2975-en.html 4100 - http://ijrr.com/article-1-2975-en.pdf SO - Int-J-Radiat-Res 3 ABĀ  - Background: Radiation-induced lung injury is a common complication after esophageal, breast, etc. cancer radiotherapy. We aimed to evaluate the radioprotective effect of arbutin on acute radiation-induced lung damage in male rats. Materials and Methods: Fifty-two male Wistar rats were divided into 4 groups: (i) control group (n = 10), (ii) vehicle group (n = 10, received distilled water intraperitoneally (ip)), (iii) X-irradiation only (n=16, chest was irradiated to a single dose of 20 Gy x-rays) and (iv) arbutin + X-irradiation (n=16, 75 mg/kg of arbutin 2 hours before irradiation (ip), and then their chest was exposed to 20 Gy x-rays). For histopathological investigation, 8 animals of each group were sacrificed 8 weeks after treatment and the rest of them were sacrificed 3 months after treatment. Results: The histopathological analysis in 8 weeks after X-irradiation showed that there was a significant increase in inflammatory in X-irradiation only group compared to control group. The administration of arbutin 2 hours prior to X-irradiation significantly reduced inflammation and inflammatory factors such as macrophages, mast cell and neutrophil in arbutin + X-irradiation group compared to X-irradiation only group (P<0.05). The histopathologic investigation performed 3 months after lung irradiation indicated a significant reduction in fibrosis formation in arbutin + X-irradiation group compared to irradiation only group (P<0.05). Localized chest X-irradiation with 20 Gy caused histopathologic damage to the lungs for short -term. Conclusion: Arbutin has a great potential in reducing the histopathologic damage to lung tissue after thoracic irradiation. CP - IRAN IN - Department of Anatomical Sciences, Afzalipour School of Medicine, Kerman University of Medical Sciences, Kerman, Iran LG - eng PB - Int-J-Radiat-Res PG - 413 PT - Original Research YR - 2020