%0 Journal Article %A Chen, J. %A Xiao, Y. %A Wu, L. %A Xiao, F. %A Wang, Q. %A Hong, J. %A Zhu, P. %T Radiosensitization of [Ru(bpy)2(phen)]Cl2 on nasopharyngeal carcinoma cells %J International Journal of Radiation Research %V 18 %N 3 %U http://ijrr.com/article-1-3075-en.html %R 10.18869/acadpub.ijrr.18.3.549 %D 2020 %K [Ru(bpy)2(phen)]Cl2, nasopharyngeal carcinoma cells, P53 gene, radiosensitization., %X Background: To investigate effect of radiosensitization of [Ru(bpy)2(phen)]Cl2 complex on nasopharyngeal carcinoma cell line CNE1 and its mechanism. Materials and Methods: Nasopharyngeal carcinoma cell line CNE1 in vitro culture was divided into control group, light irradiation group (4 Gy, 6 MV photonic line), simple metal ruthenium complex treatment group (Ru group, 100 μmol/L [Ru(bpy)2(phen)]Cl2) and metal ruthenium complex combined with radiotherapy group (Combined radiotherapy group, cells were irradiated with 4 Gy and 6 MV photons at 2 days after 100 μmol/L [Ru(bpy)2(phen)]Cl2). Results: Transcriptional level of P53 gene in combined radiotherapy group was higher than that in the other groups (P<0.001). Inhibition rate of combined radiotherapy group was higher than that of Ru group and irradiation group (P<0.001). Apoptotic rate was the highest (P<0.05) in the combined radiotherapy group, and irradiation group was higher than Ru group and control group (P<0.05). Survival rate of Ru group was lower than that of control group under the same radiation dose (P<0.05), and the radiotherapy sensitization ratio was 1.227 (Dq ratio). Conclusion: [Ru(bpy)2(phen)]Cl2 increases the sensitivity of nasopharyngeal carcinoma cell line CNE1 to X-ray, which may be related to increase of P53 gene expression. %> http://ijrr.com/article-1-3075-en.pdf %P 549-555 %& 549 %! [Ru(bpy)2(phen)]Cl2 and nasopharyngeal carcinoma %9 Original Research %L A-10-1-862 %+ Department of Radiotherapy, Fujian Medical University Union Hospital, Fuzhou 350001, and the Third Affiliated Hospital, Fujian Medical University, Fuzhou 350108, People's Republic of China %G eng %@ 2322-3243 %[ 2020