RT - Journal Article T1 - Efficacy of Hematoporphyrin mediated photo-sonodynamic therapy on mice breast cancer JF - Int-J-Radiat-Res YR - 2022 JO - Int-J-Radiat-Res VO - 20 IS - 3 UR - http://ijrr.com/article-1-4325-en.html SP - 555 EP - 561 K1 - Photodynamic therapy K1 - sonodynamic therapy K1 - laser K1 - ultrasound K1 - breast cancer. AB - Background: A combination of photodynamic and sonodynamic therapy (PSDT) may be a non-invasive method for cancer treatment, which incorporates a combination of low-intensity ultrasound, laser radiation, and a sensitizer agent. The goal of this research was to evaluate the effect of PSDT with Hematoporphyrin-encapsulated Mesoporous silica nanoparticles (HP-MSNs) as a sensitizer in the management of mice breast adenocarcinoma. Materials and Methods: One hundred and fifty-six female mice (tumor grafted) were separated into 26 groups; including sham, laser (650 nm), 4 groups of laser + HP or MSN-HP (2.5 and 5 mg/kg), 4 groups of laser + ultrasound (1and 3 MHz; 1, 2 W/cm2), 16 groups of PSDT + HP or HP-MSN. The tumor growth factors were used to assess the procedure findings. Results: The results indicate that PSDT with an injection of HP or HP-MSN is effective in delaying tumor growth (P<0.05). Overall comparison of data showed a non-significant difference between PSDT with HP-MSN groups. The time of T2 and T5 in the groups of PSDT with HP-MSN were increased in comparison with sham and that of PSDT with HP groups (P<0.05). The tumor growth inhibition ratio increased in all PSDT groups. This increase was transient and declined over 30 days of treatment. PSDT + HP-MSN had Grade I, while other groups had Grade III malignancy in the histological study. Conclusion: The research gave profound findings involving the employ of PSDT with HP-MSN as a photo/sonosensitizer for treating breast adenocarcinoma implanted in mice. LA eng UL http://ijrr.com/article-1-4325-en.html M3 10.52547/ijrr.20.3.6 ER -