@ARTICLE{Abedi, author = {Shanei, A. and Amouheidari, A. and Abedi, I. and Kazemzadeh, A. and Jaafari, A. and }, title = {Radiobiological comparison of 3D conformal and intensity modulated radiation therapy in the treatment of left-sided breast cancer}, volume = {18}, number = {2}, abstract ={Background: The current study aimed to compare the tumor control probability (TCP) and normal tissue complication probability (NTCP) of three-dimensional conformal radiation therapy (3D-CRT) and intensity-modulated radiation therapy (IMRT) for left-sided breast cancer using radiobiological models. Methods: This study was conducted on 30 patients with left-sided breast cancer, who were planned for 3D-CRT and 6-9 fields IMRT treatments using the PROWESS treatment planning system. The planning target volume (PTV) dose of 50 Gy was administered for the 3D-CRT and IMRT plans, respectively. The Niemierko’s equivalent uniform dose (EUD) model was utilized for the estimation of tumor control probability (TCP) and normal tissue complication probability (NTCP). Results: According to the results, the mean TCP values for 3D-CRT, 6-fields IMRT, and 9-fields IMRT plans were 99.07 ±0.07, 99.24 ±0.05 and 99.28 ±0.04, respectively, showing no statistically significant difference. The NTCPs of the lung and heart were considerably lower in the IMRT plans, compared to those in the 3D-CRT plans. Conclusions: From the radiobiological point of view, our results indicated that 3D-CRT produces a lower NTCP for ipsilateral lung. In contrast, for TCP calculations, there was a higher gain with IMRT plans compared to 3D-CRT plans. }, URL = {http://ijrr.com/article-1-2910-en.html}, eprint = {http://ijrr.com/article-1-2910-en.pdf}, journal = {International Journal of Radiation Research}, doi = {10.18869/acadpub.ijrr.18.2.315}, year = {2020} }